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ASAH1 抗体 (AA 88-182)

ASAH1 适用: 人, 犬 WB, IF 宿主: 小鼠 Monoclonal 23-Acid Ceramidase unconjugated
产品编号 ABIN968809
发货至: 中国
  • 抗原 See all ASAH1 抗体
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    抗原表位
    • 15
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 88-182
    适用
    • 29
    • 22
    • 6
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 犬
    宿主
    • 40
    • 4
    小鼠
    克隆类型
    • 40
    • 4
    单克隆
    标记
    • 20
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASAH1 antibody is un-conjugated
    应用范围
    • 33
    • 14
    • 13
    • 13
    • 10
    • 10
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Acid Ceramidase aa. 88-182
    克隆位点
    23-Acid Ceramidase
    亚型
    IgG1
    Top Product
    Discover our top product ASAH1 Primary Antibody
  • 限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Ferlinz, Kopal, Bernardo, Linke, Bar, Breiden, Neumann, Lang, Schuchman, Sandhoff: "Human acid ceramidase: processing, glycosylation, and lysosomal targeting." in: The Journal of biological chemistry, Vol. 276, Issue 38, pp. 35352-60, (2001) (PubMed).

    Strelow, Bernardo, Adam-Klages, Linke, Sandhoff, Krönke, Adam: "Overexpression of acid ceramidase protects from tumor necrosis factor-induced cell death." in: The Journal of experimental medicine, Vol. 192, Issue 5, pp. 601-12, (2000) (PubMed).

    Bernardo, Hurwitz, Zenk, Desnick, Ferlinz, Schuchman, Sandhoff: "Purification, characterization, and biosynthesis of human acid ceramidase." in: The Journal of biological chemistry, Vol. 270, Issue 19, pp. 11098-102, (1995) (PubMed).

  • 抗原
    ASAH1 (N-Acylsphingosine Amidohydrolase (Acid Ceramidase) 1 (ASAH1))
    别名
    Acid Ceramidase (ASAH1 产品)
    别名
    AC antibody, ACDase antibody, ASAH antibody, PHP antibody, PHP32 antibody, SMAPME antibody, 2310081N20Rik antibody, Asah antibody, MGC82286 antibody, asah1 antibody, zgc:101637 antibody, ASAH1 antibody, zgc:66026 antibody, N-acylsphingosine amidohydrolase 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1 L homeolog antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1a antibody, Acid ceramidase antibody, N-acylsphingosine amidohydrolase (acid ceramidase) 1b antibody, ASAH1 antibody, Asah1 antibody, asah1.L antibody, asah1a antibody, asah-1 antibody, asah1b antibody
    背景
    Ceramide is a sphingolipid that exhibits a wide variety of functions, including monocyte differentiation, apoptosis, neurite outgrowth, and Ca2+ transport. It also serves as the precursor of many sphingolipids and anchors these into the outer leaflet of the plasma membrane via hydrophobic interactions. Acid ceramidase is a lysosomal enzyme that was purified from human urine. It is synthesized as a 55kDa precursor protein, which is then processesed into the mature alpha-subunit (13kDa) and beta-subunit (40kDa). Acid ceramidase catalyzes the hydrolysis of ceramide into free fatty acid and sphingosine. Sphingosine, and its phosphorylated form, sphingosine-1-phosphate (SPP), have been shown to inhibit PKC activity and act as a second messenger in cell proliferation and differentiation. Acid ceramidase is also the cause of a lysosomal storage disorder known as Farber’s disease. This disease is characterized by an accumulation of ceramide in tissues, leading to swelling and pain of the joints and extremities, pulmonary insufficiency, and death at an early age. Thus, acid ceramidase is necessary in the hydrolysis of ceramide and is the cause of Farber’s disease.
    分子量
    13 kDa
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