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Calreticulin 抗体 (AA 270-390)

Name: Calreticulin 抗体 (AA 270-390)
SKU: ABIN968752
Availability: OutOfStock

CALR 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 16-Calreticulin unconjugated

Western blot analysis of calreticulin on a mouse testis lysate. (Calreticulin 抗体 (AA 270-390))

Immunoflourescence staining of the human lung cell line, WI38. (Calreticulin 抗体 (AA 270-390))

2 images

(4 references)

产品编号 ABIN968752

发货至: 中国

Datasheet as PDF

抗原 See all Calreticulin (CALR) 抗体

Calreticulin (CALR)
抗原表位
16

12

8

7

6

4

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 270-390
适用
125

63

46

10

9

7

7

6

5

4

4

4

3

1

1

1

1

1
人, 小鼠, 大鼠
宿主
119

9

2

1
小鼠
Compatible Secondaries
克隆类型
113

18
单克隆
标记
64

13

11

7

5

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Calreticulin antibody is un-conjugated
应用范围
101

52

47

37

28

23

22

16

14

13

3

2

2

2

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

交叉反应

人, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Mouse Calreticulin aa. 270-390

克隆位点

16-Calreticulin

亚型

IgG1

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CALR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) (AA 18-193) antibody
CALR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) antibody
CALR 适用: 人 WB, ELISA, IHC, ICC 宿主: 小鼠 Monoclonal 1G6A7 unconjugated

anti-Calreticulin (CALR) (AA 18-417) antibody
CALR 适用: 人 WB, ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7B3D7 unconjugated

anti-Calreticulin (CALR) (AA 1-417) antibody
CALR 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1G11-1A9 unconjugated

anti-Calreticulin (CALR) (N-Term) antibody
CALR 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) antibody
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-Calreticulin (CALR) (AA 277-305) antibody
CALR 适用: 人, 大鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB21112 unconjugated

anti-Calreticulin (CALR) antibody (HRP)
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal HRP

anti-Calreticulin (CALR) antibody (FITC)
CALR 适用: 人 WB, IHC, IP, IF, FACS, ICC 宿主: 兔 Polyclonal FITC

说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Ito, Seyama, Kubota: "Calreticulin is directly involved in anti-alpha3 integrin antibody-mediated secretion and activation of matrix metalloprotease-2." in: Biochemical and biophysical research communications, Vol. 283, Issue 2, pp. 297-302, (2001) (PubMed).

Saito, Ihara, Leach, Cohen-Doyle, Williams: "Calreticulin functions in vitro as a molecular chaperone for both glycosylated and non-glycosylated proteins." in: The EMBO journal, Vol. 18, Issue 23, pp. 6718-29, (2000) (PubMed).

Nair, Wearsch, Mitchell, Wassenberg, Gilboa, Nicchitta: "Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 11, pp. 6426-32, (1999) (PubMed).

Mazzarella, Gold, Cunningham, Green: "Determination of the sequence of an expressible cDNA clone encoding ERp60/calregulin by the use of a novel nested set method." in: Gene, Vol. 120, Issue 2, pp. 217-25, (1992) (PubMed).
抗原

Calreticulin (CALR)

别名

Calreticulin (CALR 产品)

背景

Proteins undergo numerous modifications, including folding, translocation, and degradation. During such modifications, polypeptides are rarely in a native, stable state. Molecular chaperones are a diverse group of proteins that modulate polypeptide stability through ATP-dependent folding. Many chaperone proteins are found in the endoplasmic reticulum (ER). Calreticulin is a luminal ER protein that is 39% homologous to the ER chaperone protein, calnexin. Calreticulin contains a C-terminal KDEL ER retention signal, and can bind Ca2+, Zn2+, ATP, and the proteins, ERp57 and protein disulfide isomerase. The molecular chaperone activities of calreticulin may include folding of both Asn-linked glycoproteins and non-glycosylated proteins. In addition, calreticulin is a component of MHC I/transporter associated with Ag presentation (TAP) complex where it may function in peptide assembly onto nascent class I molecules. Calreticulin may also function in integrin signaling, since it binds a3-integrin subunits and regulates integrin-mediated metalloprotease secretion. Thus, calreticulin may be involved in Ca2+ storage, cell adhesion, and protein folding. This antibody is routinely tested by western blot analysis.

分子量

60 kDa

途径

Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response