HIP1R 抗体 (AA 560-772)
(3 references)-
- 抗原 See all HIP1R 抗体
- HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))
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抗原表位
- AA 560-772
- 适用
- 人, 大鼠, 小鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HIP1R antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 人, 犬, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Hip1R aa. 560-772
- 克隆位点
- 44-Hip1R
- 亚型
- IgG1
- Top Product
- Discover our top product HIP1R Primary Antibody
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anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 1-1068) antibody
HIP1R 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 1-1068) antibodyHIP1R 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 969-1066) antibodyHIP1R 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3E10 unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 304-487) antibodyHIP1R 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (N-Term) antibodyHIP1R 适用: 人 WB, IHC, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 771-1012) antibodyHIP1R 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 98-126), (N-Term) antibodyHIP1R 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB18066 unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 300-600) antibodyHIP1R 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Interacting Protein 1 Related (HIP1R) (AA 105-133), (N-Term) antibodyHIP1R 适用: 人 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis." in: Science (New York, N.Y.), Vol. 291, Issue 5506, pp. 1047-51, (2001) (PubMed).
: "An actin-binding protein of the Sla2/Huntingtin interacting protein 1 family is a novel component of clathrin-coated pits and vesicles." in: The Journal of cell biology, Vol. 147, Issue 7, pp. 1503-18, (2000) (PubMed).
: "Cloning, expression analysis, and chromosomal localization of HIP1R, an isolog of huntingtin interacting protein (HIP1)." in: Journal of human genetics, Vol. 43, Issue 4, pp. 268-71, (1999) (PubMed).
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: "Role of the ENTH domain in phosphatidylinositol-4,5-bisphosphate binding and endocytosis." in: Science (New York, N.Y.), Vol. 291, Issue 5506, pp. 1047-51, (2001) (PubMed).
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- 抗原
- HIP1R (Huntingtin Interacting Protein 1 Related (HIP1R))
- 别名
- Hip1R (HIP1R 产品)
- 别名
- HIP12 antibody, HIP3 antibody, ILWEQ antibody, AA410023 antibody, mKIAA0655 antibody, HIP1R antibody, hip1r antibody, hip3 antibody, hip12 antibody, ilweq antibody, DKFZp469N2015 antibody, hip1 antibody, MGC78813 antibody, huntingtin interacting protein 1 related antibody, huntingtin interacting protein 1 related b antibody, huntingtin interacting protein 1 related L homeolog antibody, HIP1R antibody, Hip1r antibody, hip1rb antibody, hip1r antibody, hip1r.L antibody
- 背景
- Clathrin is the major protein component in the coat formed around pits and vesicles involved in receptor-mediated endocytosis. Clathrin forms a non-covalently bound triskelion structure composed of three heavy chains (192kDa each) and three light chains (23-25kDa each). A variety of proteins facilitate receptor-mediated endocytosis through association with clathrin-coated vesicles. Huntingtin interacting protein 1 (Hip1) is an actin-binding protein that interacts with Huntingtin protein, and has been implicated in vesicular transport defects found in Huntingtin's disease. Hip1 related protein (Hip1R) is another actin binding protein that contains an epsin NH2-terminal homology (ENTH)domain, three coiled-coil regions, a leucine zipper, and a talin-like actin binding domain. Hip1R mRNA is widely expressed, and Hip1R protein is enriched in the cell cortex and perinuclear region. The ENTH domain of Hip1R is required for binding to phosphatidylinositol-4,5-bisphosphate, and this complex is essential for clathrin-mediated endocytosis. In addition, Hip1R colocalizes with clathrin, AP-2 and endocytosed transferrin. Thus, Hip1R may facilitate interactions between clathrin-coated pits and actin during endocytosis.
- 分子量
- 120 kDa
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