MTTP 抗体 (AA 91-288)
(6 references)-
- 抗原 See all MTTP 抗体
- MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
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抗原表位
- AA 91-288
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适用
- 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MTTP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse MTP aa. 91-288
- 克隆位点
- 8-MTP
- 亚型
- IgG2a
- Top Product
- Discover our top product MTTP Primary Antibody
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anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 28-459) antibody
MTTP 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 19-151) antibodyMTTP 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 1-130) antibodyMTTP 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 878-911), (C-Term) antibodyMTTP 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB51778 unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (Internal Region) antibodyMTTP 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) antibodyMTTP 适用: 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) antibodyMTTP 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 1-151) antibodyMTTP 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (N-Term) antibodyMTTP 适用: 人, 小鼠, 大鼠, 马, 兔, Cow, 犬, 豚鼠, Bat, Hamster, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Microsomal Triglyceride Transfer Protein (MTTP) (AA 1-130) antibodyMTTP 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968543, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice." in: Journal of lipid research, Vol. 49, Issue 9, pp. 2013-22, (2008) (PubMed).
: "Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 5, pp. G1120-9, (2008) (PubMed).
: "Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver." in: Journal of lipid research, Vol. 48, Issue 7, pp. 1499-510, (2007) (PubMed).
: "A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein." in: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 30372-7, (2000) (PubMed).
: "An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. ..." in: Science (New York, N.Y.), Vol. 282, Issue 5389, pp. 751-4, (1998) (PubMed).
: "Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization." in: Genomics, Vol. 33, Issue 2, pp. 313-6, (1997) (PubMed).
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: "ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice." in: Journal of lipid research, Vol. 49, Issue 9, pp. 2013-22, (2008) (PubMed).
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- 抗原
- MTTP (Microsomal Triglyceride Transfer Protein (MTTP))
- 别名
- MTP (MTTP 产品)
- 别名
- ABL antibody, MTP antibody, 1810043K16Rik antibody, CG9342 antibody, CT3751 antibody, Dmel\\CG9342 antibody, dMTP antibody, wu:fd36b01 antibody, zgc:111876 antibody, microsomal triglyceride transfer protein antibody, Microsomal triacylglycerol transfer protein antibody, MTTP antibody, Mttp antibody, Mtp antibody, mttp antibody
- 背景
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The microsomal triglyceride transfer protein (MTP) catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between membranes within the lumen of microsomes in hepatocytes and enterocytes. MTP forms a heterodimer with the 58 kDa protein disulfide isomerase. PDI catalyzes the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configuration within proteins. MTP is mutated in abetalipoproteinemia, which results from defects in apolipoprotein-B (apoB)-containing lipoproteins. A lack of MTP expression prevents secretion of apoB from mammalian cells, leading to intracellular degradation. In the C-terminal region, MTP has structural homology to apoB and the lamprey lipovitellin protein. This region contains a membrane binding helix (Helix A), and a triglyceride binding helix (Helix B). Mutations in Helix B cause abetalipoproteinemia. In addition, inhibitors of MTP activity may be important therapeutics for lowering atherogenic lipoprotein levels. Thus, MTP is a microsomal protein that is required for transport of lipids between membranes in liver and small intestines.
Synonyms: Microsomal Triglyceride transfer Protein - 分子量
- 97 kDa
- 途径
- Transition Metal Ion Homeostasis
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