DLC1 抗体 (AA 47-249)
(3 references)-
- 抗原 See all DLC1 抗体
- DLC1 (Deleted in Liver Cancer 1 (DLC1))
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抗原表位
- AA 47-249
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This DLC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Please refer to us for technical protocols. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human DLC-1 aa. 47-249
- 克隆位点
- 3-DLC
- 亚型
- IgG1
- Top Product
- Discover our top product DLC1 Primary Antibody
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anti-Deleted in Liver Cancer 1 (DLC1) (N-Term) antibody
Verified DLC1 适用: 人, 小鼠 IHC, ELISA, IF 宿主: 山羊 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (N-Term) antibodyDLC1 适用: 人, 小鼠, 大鼠 IHC, WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (AA 204-463) antibodyDLC1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (N-Term) antibodyDLC1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) antibodyDLC1 适用: 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (AA 1-1528) antibodyDLC1 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (AA 1-1528) antibodyDLC1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (AA 1224-1273) antibodyDLC1 适用: 人, 小鼠, 大鼠, Cow, Pig, 犬, 豚鼠, 马, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (C-Term) antibodyDLC1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Deleted in Liver Cancer 1 (DLC1) (AA 61-110) antibodyDLC1 适用: 人, 小鼠, 大鼠 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17757-62, (1999) (PubMed).
: "Cloning, characterization, and chromosomal localization of a gene frequently deleted in human liver cancer (DLC-1) homologous to rat RhoGAP." in: Cancer research, Vol. 58, Issue 10, pp. 2196-9, (1998) (PubMed).
: "A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities." in: The EMBO journal, Vol. 14, Issue 2, pp. 286-91, (1995) (PubMed).
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: "Morphological changes and detachment of adherent cells induced by p122, a GTPase-activating protein for Rho." in: The Journal of biological chemistry, Vol. 274, Issue 25, pp. 17757-62, (1999) (PubMed).
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- 抗原
- DLC1 (Deleted in Liver Cancer 1 (DLC1))
- 别名
- DLC-1 (DLC1 产品)
- 别名
- ARHGAP7 antibody, HP antibody, STARD12 antibody, p122-RhoGAP antibody, rhogap7 antibody, DLC-1 antibody, StARD12 antibody, Dlc-1 antibody, A730069N07Rik antibody, Arhgap7 antibody, dlc-1 antibody, RhoGAP antibody, Dlc1 antibody, DLC1 Rho GTPase activating protein antibody, DLC1 Rho GTPase activating protein S homeolog antibody, rho GTPase-activating protein 7 antibody, deleted in liver cancer 1 antibody, DLC1 antibody, dlc1.S antibody, dlc1 antibody, LOC100456847 antibody, Dlc1 antibody, LOC100729904 antibody
- 背景
- Members of the Ras superfamily of GTPases are distantly related to the heterotrimeric G proteins and shuttle between inactive and active GTP-bound forms. Conversion between these forms is controlled by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Rho is a GTPase that regulates cell morphology and motility in response to extracellular signals. p190A, p190B, and p122 RhoGAPs all contain RhoGAP domains and regulate the GTPase activity of Rho. p122 RhoGAP exhibits GAP activity for RhoA, but not Rac1, and binds and activates PLC-delta1. Microinjection of p122 RhoGAP suppresses LPA-induced formation of stress fibers and focal adhesions. Deleted in liver cancer-1 (DLC-1) was identified by its frequent deletion in liver cancer and is a human homologue of rat p122 RhoGAP. DLC-1 is expressed in many hepatocellular carcinoma tissues and cell lines and could be an important tumor suppressor gene. In normal human tissues, DLC-1 is expressed widely with the highest expression in heart and lung. Both p122 RhoGAP and DLC-1 have RhoGAP domains toward their C-terminal regions, which is thought to be important for regulation of Rho GTPase activity in many tissues. This antibody is routinely tested by western blot analysis.
- 分子量
- 123 kDa
- 途径
- Tube Formation, Positive Regulation of Endopeptidase Activity
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