Thyroid Hormone Receptor Interactor 11 (TRIP11) (AA 159-365) 抗体
TRIP11
适用: 人
WB, IF
宿主: 小鼠
Monoclonal
15-GMAP
unconjugated
(3 references)-
- 抗原 See all Thyroid Hormone Receptor Interactor 11 (TRIP11) 抗体
- Thyroid Hormone Receptor Interactor 11 (TRIP11)
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抗原表位
- AA 159-365
- 适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- 非结合性
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human GMAP-210 aa. 159-365
- 克隆位点
- 15-GMAP
- 亚型
- IgG1
- Top Product
- Discover our top product TRIP11 Primary Antibody
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4443-8, (1999) (PubMed).
: "GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein." in: The Journal of cell biology, Vol. 145, Issue 1, pp. 83-98, (1999) (PubMed).
: "A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 17, pp. 9040-5, (1997) (PubMed).
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: "Thyroid hormone, T3-dependent phosphorylation and translocation of Trip230 from the Golgi complex to the nucleus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 8, pp. 4443-8, (1999) (PubMed).
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- 抗原
- Thyroid Hormone Receptor Interactor 11 (TRIP11)
- 别名
- GMAP-210 (TRIP11 产品)
- 别名
- ACG1A antibody, CEV14 antibody, GMAP-210 antibody, TRIP-11 antibody, TRIP230 antibody, cb423 antibody, sb:cb423 antibody, sb:cb721 antibody, wu:fb71d07 antibody, MGC79667 antibody, 2610511G22Rik antibody, 3110031G15Rik antibody, 6030460N08Rik antibody, AI450776 antibody, thyroid hormone receptor interactor 11 antibody, thyroid hormone receptor interactor 11 L homeolog antibody, TRIP11 antibody, trip11 antibody, trip11.L antibody, Trip11 antibody
- 背景
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Trip230 was identified as a protein that interacts with retinoblastoma protein (Rb) and the thyroid hormone receptor (TR). The structure of Trip230 includes five coiled-coil segments separated by non-helical linkers, N-terminal and C-terminal leucine zipper domains, and multiple phosphorylation sites. Trip230 is ubiquitously expressed and localized to the Golgi. During cell cycle progression, a significant portion of Trip230 translocates to the nucleus. In addition, activation of TR with thyroid hormone (T3) leads to phosphorylation of Trip230, as well as Trip230 translocation from the Golgi to the nucleus. Interestingly, Trip230 has also been identified as a Golgi microtubule-associated protein of 210 kDa (GMAP-210). In vitro , GMAP-210 can bind to the minus end of alpha-tubulin and gamma-tubulin via its C-terminal region, while the N-terminal region is involved in Golgi binding. Overexpression of GMAP-210 leads to enlargement of the Golgi apparatus and alterations in the microtubule cytoskeleton. Thus, GMAP-210/Trip230 is thought to function both as a TR coactivator and as a microtubule-binding protein that anchors the Golgi to the microtubule cytoskeleton.
Synonyms: Trip230 - 分子量
- 210 kDa
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