ARHGEF7 抗体 (AA 351-453)
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- 抗原 See all ARHGEF7 抗体
- ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))
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抗原表位
- AA 351-453
- 适用
- 大鼠, 小鼠, 小鸡, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ARHGEF7 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 小鸡, 犬, 小鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat betaPIX aa. 351-453
- 克隆位点
- 23-bPIX
- 亚型
- IgG1
- Top Product
- Discover our top product ARHGEF7 Primary Antibody
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anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) antibody
ARHGEF7 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) (AA 1-250) antibodyARHGEF7 适用: 人 ELISA, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) antibodyARHGEF7 适用: 人, 大鼠, 小鼠 WB, ELISA, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) (AA 1-188) antibodyARHGEF7 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) (AA 654-688) antibodyARHGEF7 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB56222 unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) (AA 102-190) antibodyARHGEF7 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) (AA 1-646) antibodyARHGEF7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) antibody (Biotin)ARHGEF7 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal Biotin
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) antibody (HRP)ARHGEF7 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal HRP
anti-rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7) antibody (FITC)ARHGEF7 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal FITC
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling." in: The Journal of cell biology, Vol. 145, Issue 4, pp. 851-63, (1999) (PubMed).
: "A novel regulator of p21-activated kinases." in: The Journal of biological chemistry, Vol. 273, Issue 37, pp. 23633-6, (1998) (PubMed).
: "PAK kinases are directly coupled to the PIX family of nucleotide exchange factors." in: Molecular cell, Vol. 1, Issue 2, pp. 183-92, (1998) (PubMed).
: "Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 794-8, (1997) (PubMed).
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: "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling." in: The Journal of cell biology, Vol. 145, Issue 4, pp. 851-63, (1999) (PubMed).
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- 抗原
- ARHGEF7 (rho Guanine Nucleotide Exchange Factor (GEF) 7 (ARHGEF7))
- 别名
- beta PIX (ARHGEF7 产品)
- 别名
- BETA-PIX antibody, COOL-1 antibody, COOL1 antibody, Nbla10314 antibody, P50 antibody, P50BP antibody, P85 antibody, P85COOL1 antibody, P85SPR antibody, PAK3 antibody, PIXB antibody, cool1 antibody, p50 antibody, p85 antibody, pak3 antibody, pixb antibody, ARHGEF7 antibody, P85spr antibody, Pak3bp antibody, Cool antibody, PIX antibody, betaPix antibody, betaPix-b antibody, betaPix-c antibody, cool-1 antibody, mKIAA0142 antibody, p85Cool1 antibody, p85SPR antibody, arhgef7 antibody, bbh antibody, bpix antibody, im:7142367 antibody, wu:fc35h08 antibody, zgc:101775 antibody, Rho guanine nucleotide exchange factor 7 antibody, Rho guanine nucleotide exchange factor 7 S homeolog antibody, ankyrin repeat domain 10 antibody, Rho guanine nucleotide exchange factor (GEF7) antibody, Rho guanine nucleotide exchange factor (GEF) 7b antibody, ARHGEF7 antibody, arhgef7.S antibody, arhgef7 antibody, ANKRD10 antibody, Arhgef7 antibody, arhgef7b antibody
- 背景
- The activity of PAK family kinases is regulated through interaction with the small GTPases Cdc42 and Rac1. PAKs are activated by the GTP-bound form of Cdc-42 and Rac1, and recruitment of PAKs to focal complexes has been implicated in Cdc42- and Rac1-dependent regulation of focal contact formation. PAK-interacting exchange factor (PIX) was identified in a screen for proteins that bind PAKs. Two forms of PIX have been identified: an 85 kDa protein designated alphaPIX and a 78 kDa protein designated betaPIX. These proteins have 80% identity in their overlapping regions, which include myosin-like, pleckstrin (PH), Dbl (DH), and SH3 domains. In addition, alphaPIX contains a calponin-like domain at the N-terminus. The expression of betaPIX is ubiquitous, while alphaPIX is expressed in heart, muscle, and thymus. PIX can act as a guanine nuleotide exchange factor for Rac1 and co-transfection of betaPIX, Cdc42, and alphaPAK results in increased alphaPAK activity. PIX binding to PAK is required for localization of PAKs to focal complexes and injection of betaPIX leads to rac1-dependent membrane ruffling. Thus, PIX is important for PAK localization and activity during small GTPase-dependent regulation of cell morphology.
- 分子量
- 78 kDa
- 途径
- EGFR Signaling Pathway, Neurotrophin Signaling Pathway, EGFR Downregulation
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