KSR1 抗体 (AA 90-203)
(4 references)-
- 抗原 See all KSR1 抗体
- KSR1 (Kinase Suppressor of Ras 1 (KSR1))
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抗原表位
- AA 90-203
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适用
- 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This KSR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse KSR-1 aa. 90-203
- 克隆位点
- 15-KSR
- 亚型
- IgG1
- Top Product
- Discover our top product KSR1 Primary Antibody
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anti-Kinase Suppressor of Ras 1 (KSR1) (AA 404-598) antibody
KSR1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 301-400) antibodyKSR1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6C7 unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 320-420) antibodyKSR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 358-407) antibodyKSR1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 601-750) antibodyKSR1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (pSer392) antibodyKSR1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (AA 301-400) antibodyKSR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) antibodyKSR1 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (Tyr40) antibodyKSR1 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Kinase Suppressor of Ras 1 (KSR1) (pSer392) antibodyKSR1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization." in: Molecular and cellular biology, Vol. 19, Issue 8, pp. 5523-34, (1999) (PubMed).
: "KSR stimulates Raf-1 activity in a kinase-independent manner." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 24, pp. 12792-6, (1998) (PubMed).
: "Kinase suppressor of Ras is ceramide-activated protein kinase." in: Cell, Vol. 89, Issue 1, pp. 63-72, (1997) (PubMed).
: "KSR, a novel protein kinase required for RAS signal transduction." in: Cell, Vol. 83, Issue 6, pp. 879-88, (1996) (PubMed).
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: "Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization." in: Molecular and cellular biology, Vol. 19, Issue 8, pp. 5523-34, (1999) (PubMed).
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- 抗原
- KSR1 (Kinase Suppressor of Ras 1 (KSR1))
- 别名
- KSR-1 (KSR1 产品)
- 别名
- CG2899 antibody, Dmel\\CG2899 antibody, EK3-1 antibody, KSR antibody, KSR-1 antibody, Ksr antibody, Ksr-1 antibody, SR3-1 antibody, dKsr antibody, l(3)j5E2 antibody, AW492498 antibody, B-KSR1 antibody, D11Bhm183e antibody, D11Bhm184e antibody, RSU2 antibody, hb antibody, kinase suppressor of ras 1 antibody, kinase suppressor of ras antibody, KSR1 antibody, ksr antibody, Ksr1 antibody
- 背景
- Proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. In mammalian cells there are four true Ras proteins (encoded by Ha-ras, N-ras, Ki-rasA, and Ki-rasB). These proteins relay signals from tyrosine kinases at the plasma membrane to the nucleus via a network of Ser/Thr kinases that includes the MAP kinase (Raf-MEK-ERK) pathway. Kinase suppressor of Ras (KSR-1) was discovered in a genetic screen to identify mutations that suppress constitutively active Ras mutants. KSR-1 contains five domains that are conserved areas (CA) in Drosophila, mouse, and human. CA1 is a unique domain, CA2 is a proline-rich domain, CA3 is a cysteine-rich domain, CA4 is a Ser/Thr rich region, and CA5 contains a C-terminal kinase domain similar to that of Raf. In COS7 cells, ceramide induces the autophosphorylation of KSR-1 and KSR-1-induced phosphorylation and activation of Raf. In addition, overexpression of KSR-1 in 293T cells leads to recruitment of MEK to a 700 kDa protein complex and translocates MEK from the soluble to the membrane-associated fraction. Thus, KSR-1 may have important kinase and scaffolding activities during Ras-related signaling. This antibody is routinely tested by western blot analysis.
- 分子量
- 115 kDa
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