AKAP4 抗体 (AA 555-675)
(4 references)-
- 抗原 See all AKAP4 抗体
- AKAP4 (A Kinase (PRKA) Anchor Protein 4 (AKAP4))
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抗原表位
- AA 555-675
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适用
- 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This AKAP4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse AKAP82 aa. 555-675
- 克隆位点
- 25-AKAP82
- 亚型
- IgG1
- Top Product
- Discover our top product AKAP4 Primary Antibody
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anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) antibody
AKAP4 适用: 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) (AA 1-100) antibodyAKAP4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4C10 unconjugated
anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) (AA 189-340) antibodyAKAP4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) (AA 1-100) antibodyAKAP4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4G1 unconjugated
anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) (AA 1-100) antibodyAKAP4 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-A Kinase (PRKA) Anchor Protein 4 (AKAP4) (N-Term) antibodyAKAP4 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "A-kinase anchoring proteins: protein kinase A and beyond." in: Current opinion in cell biology, Vol. 12, Issue 2, pp. 217-21, (2000) (PubMed).
: "Identification of tethering domains for protein kinase A type Ialpha regulatory subunits on sperm fibrous sheath protein FSC1." in: The Journal of biological chemistry, Vol. 273, Issue 51, pp. 34384-90, (1999) (PubMed).
: "An X-linked gene encodes a major human sperm fibrous sheath protein, hAKAP82. Genomic organization, protein kinase A-RII binding, and distribution of the precursor in the sperm tail." in: The Journal of biological chemistry, Vol. 273, Issue 48, pp. 32135-41, (1998) (PubMed).
: "Characterization of Fsc1 cDNA for a mouse sperm fibrous sheath component." in: Biology of reproduction, Vol. 52, Issue 1, pp. 41-9, (1995) (PubMed).
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: "A-kinase anchoring proteins: protein kinase A and beyond." in: Current opinion in cell biology, Vol. 12, Issue 2, pp. 217-21, (2000) (PubMed).
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- 抗原
- AKAP4 (A Kinase (PRKA) Anchor Protein 4 (AKAP4))
- 别名
- AKAP82 (AKAP4 产品)
- 别名
- AKAP4 antibody, AKAP 82 antibody, AKAP-4 antibody, AKAP82 antibody, CT99 antibody, FSC1 antibody, HI antibody, PRKA4 antibody, hAKAP82 antibody, p82 antibody, Fsc1 antibody, A-kinase anchoring protein 4 antibody, A kinase (PRKA) anchor protein 4 antibody, AKAP4 antibody, Akap4 antibody
- 背景
- The cAMP-dependent Protein Kinase (PKA) is compartmentalized within the cell. To maintain the localization of PKA, the regulatory subunits interact with specific anchoring proteins. Several proteins have been identified as PKA anchoring proteins and form a family named AKAP (A-Kinase Anchor Proteins). Fifteen of the AKAP proteins contain a consensus binding motif that allows interaction with the type II regulatory subunit (RII) of the PKA holoenzyme. In addition, three other AKAPs (D-AKAP1, D-AKAP2, and fsc1/AKAP82) can associate with the type I regulatory subunit (RI) of the PKA holoenzyme. AKAP82 was isolated as a component of the mouse sperm fibrous sheath. It is a dual specificity AKAP that contains an RII-binding domain (domain A, amino acids 219 to 232) and an RI-binding domain (domain B, amino acids 335-344). In mouse, pro-AKAP82 is synthesized as a 97 kDa precursor that is transported to the flagellum where proteolytic cleavage of the N-terminal 179 amino acids produces AKAP82. Assembly of AKAP82 into the fibrous sheath surrounding the axoneme of the sperm flagellum is thought to tether PKA close to the axoneme where it can regulate flagellar motility.
- 分子量
- 82 kDa
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