CYBB 抗体 (AA 450-556)
(4 references)-
- 抗原 See all CYBB 抗体
- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
-
抗原表位
- AA 450-556
-
适用
- 小鼠, 大鼠
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This CYBB antibody is un-conjugated
-
应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠
- 产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse gp91[phox] aa. 450-556
- 克隆位点
- 53-gp91[phox]
- 亚型
- IgG1
- Top Product
- Discover our top product CYBB Primary Antibody
-
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 501-570) antibody
CYBB 适用: 人, 小鼠, 大鼠, 兔, 小鸡 WB, ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (C-Term) antibodyCYBB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (C-Term) antibodyCYBB 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) antibodyCYBB 适用: 人 WB, IHC (p), IF, ICC 宿主: 小鼠 Monoclonal 54-1 unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 442-459), (Middle Region) antibodyCYBB 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 283-570) antibodyCYBB 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (Internal Region) antibodyVerified CYBB 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Cytochrome B-245, beta Polypeptide (CYBB) (AA 100-200) antibodyCYBB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
-
- 说明
-
Related Products: ABIN968555, ABIN967389, ABIN967918, ABIN968245
- 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
-
-
: "YY1 binds five cis-elements and trans-activates the myeloid cell-restricted gp91(phox) promoter." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 29984-93, (1999) (PubMed).
: "PU.1 as an essential activator for the expression of gp91(phox) gene in human peripheral neutrophils, monocytes, and B lymphocytes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 11, pp. 6085-90, (1998) (PubMed).
: "Gp91(phox) is the heme binding subunit of the superoxide-generating NADPH oxidase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 14, pp. 7993-8, (1998) (PubMed).
: "Probing the role of the carboxyl terminus of the gp91phox subunit of neutrophil flavocytochrome b558 using site-directed mutagenesis." in: The Journal of biological chemistry, Vol. 273, Issue 11, pp. 6575-81, (1998) (PubMed).
-
: "YY1 binds five cis-elements and trans-activates the myeloid cell-restricted gp91(phox) promoter." in: The Journal of biological chemistry, Vol. 274, Issue 42, pp. 29984-93, (1999) (PubMed).
-
- 抗原
- CYBB (Cytochrome B-245, beta Polypeptide (CYBB))
- 别名
- gp91 phox (CYBB 产品)
- 别名
- zgc:64144 antibody, cgd antibody, gp91-1 antibody, gp91-phox antibody, gp91phox antibody, nox2 antibody, NOX2 antibody, cybb antibody, NOX1 antibody, AMCBX2 antibody, CGD antibody, GP91-1 antibody, GP91-PHOX antibody, GP91PHOX antibody, p91-PHOX antibody, Nox2 antibody, C88302 antibody, CGD91-phox antibody, Cgd antibody, Cyd antibody, Gp91-phox antibody, CYBB antibody, cytochrome b-245, beta polypeptide (chronic granulomatous disease) antibody, cytochrome b-245, beta polypeptide antibody, cytochrome b-245 heavy chain antibody, cytochrome b-245, beta polypeptide L homeolog antibody, cytochrome b-245 beta polypeptide antibody, cytochrome b-245 beta chain antibody, NADPH oxidase heavy chain subunit antibody, cybb antibody, CYBB antibody, cybb.L antibody, Cybb antibody, GP91-PHOX antibody
- 背景
- Although dormant in resting granulocytes, macrophages, and B lymphocytes, the neutrophil respiratory burst oxidase (NADPH-oxidase) generates superoxide and secondary oxygen-derived toxic products in response to bacteria or a variety of soluble stimuli. It is an integral membrane cytochrome, b558, which consists of two subunits, gp91[phox] and p21[phox]. Upon stimulation, cytochrome b558 forms a complex with cytosolic proteins, p67[phox], p47[phox], p40[phox], and rac2 and produces superoxide anions in a NADPH-dependent manner. In chronic granulomatous disease (CGD), severe recurrent bacterial and fungal infections result from defective NADPH-oxidase activity. The majority of CGD cases are caused by a defective gp91[phox] gene. gp91[phox], implicated as a docking site for p47[phox], is membrane glycoprotein with multiple N-terminal hydrophobic domains and a hydrophilic C-terminus. The expression of gp91[phox] is restricted to terminally differentiated phagocytes and B lymphocytes. This cell type- and developmental stage-specific expression may be controlled by transcriptional activators, such as PU.1 and YY1, and transcriptional repressors, such as CCAAT displacement protein (CDP). Endogenous mouse gp91phox shows 58 kDa band, instead of 91 kDa observed in human. Both mouse and human deglycosylated gp91 are 54 kDa. This difference may be due to less glycosylation sites in the mouse sequence.
- 分子量
- 58 kDa
-
