PIK3CA 抗体 (AA 101-300)
(5 references)-
- 抗原 See all PIK3CA 抗体
- PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
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抗原表位
- AA 101-300
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适用
- 人, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PIK3CA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human PI3-Kinase p110alpha aa. 101-300
- 克隆位点
- 19-PI3
- 亚型
- IgG1
- Top Product
- Discover our top product PIK3CA Primary Antibody
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anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 401-600) antibody
PIK3CA 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) antibodyPIK3CA 适用: 人 WB, ELISA, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 961-1068) antibodyPIK3CA 适用: 人, 小鼠, 大鼠, Cow, 兔 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 1019-1050), (C-Term) antibodyPIK3CA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB01702 unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 504-533) antibodyPIK3CA 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (pTyr317) antibodyPIK3CA 适用: 人, 小鼠, Cow WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (Internal Region) antibodyVerified PIK3CA 适用: 人 IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (N-Term) antibodyPIK3CA 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (AA 1-206), (Catalytic Subunit alpha) antibodyPIK3CA 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA) (Catalytic Subunit alpha) antibodyPIK3CA 适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 10E5 unconjugated Recombinant Antibody
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 22019-24, (1999) (PubMed).
: "Involvement of phosphatidylinositol 3-kinase in stromal cell-derived factor-1 alpha-induced lymphocyte polarization and chemotaxis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 163, Issue 7, pp. 4001-12, (1999) (PubMed).
: "Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes." in: The Journal of biological chemistry, Vol. 271, Issue 29, pp. 16987-90, (1996) (PubMed).
: "Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase." in: Science (New York, N.Y.), Vol. 268, Issue 5207, pp. 100-2, (1995) (PubMed).
: "Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene." in: Genomics, Vol. 24, Issue 3, pp. 472-7, (1995) (PubMed).
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: "p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 22019-24, (1999) (PubMed).
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- 抗原
- PIK3CA (Phosphoinositide-3-Kinase, Catalytic, alpha Polypeptide (PIK3CA))
- 别名
- PI3-Kinase p110 alpha (PIK3CA 产品)
- 别名
- CLOVE antibody, CWS5 antibody, MCAP antibody, MCM antibody, MCMTC antibody, PI3K antibody, p110-alpha antibody, C-P3K antibody, PI3-kinase antibody, PI3K-alpha antibody, pi3-k antibody, pi3k antibody, AA414921 antibody, C530050K14 antibody, p50alpha antibody, p55alpha antibody, p85alpha antibody, 6330412C24Rik antibody, caPI3K antibody, p110 antibody, p110alpha antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha antibody, Phosphoinositide-3-kinase, catalytic, alpha polypeptide antibody, phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha antibody, phosphoinositide-3-kinase regulatory subunit 1 antibody, PIK3CA antibody, GL50803_14855 antibody, pik3ca antibody, Pik3ca antibody, Pik3r1 antibody
- 背景
- Phosphatidylinositol 3 (PI3) -kinase participates in insulin-stimulated glucose uptake, PDGF-induced membrane ruffling, and G-protein receptor signaling. It exists as a heterodimer of 85 kDa (p85) and 110 kDa (p110) subunits. The p85 subunit associates with and serves as a substrate for activated growth factor receptor tyrosine kinases. p85 regulates the p110 catalytic subunit by acting as the link between PI3-kinase and the ligand-activated receptor. Four isoforms of p110 have been identified (alpha, beta, gamma, and delta). The p110alpha isoform contains an N-terminal region involved in p85 binding and a C-terminal kinase domain. p85/p110alpha-type PI kinase phosphorylates the D-3 and D-4 position of the inositol ring of PI, thereby producing PtdIns(3)P, PtdIns(3,4)P[2], PtdIns(3,4,5)P[3], PtdIns(4)P, and PtdIns(4,5) P[2]. During induction of chemotaxis by the chemokine SDF-1alpha, PI3-kinase regulates adhesion and ERM protein redistribution in the lymphocyte plasma membrane. In addition, PI3-kinases activate other signaling molecules, such as p70 S6 kinase and Akt/protein kinase B. Thus, p85/p110alpha-type PI kinase is a ubiquitously expressed kinase that is involved in a variety of cell signaling cascades.
- 分子量
- 110 kDa
- 途径
- PI3K-Akt Signaling, RTK signaling, TCR Signaling, AMPK Signaling, Interferon-gamma Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Hepatitis C, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals, VEGF Signaling
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