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CD40 抗体 (AA 71-187)

Name: CD40 抗体 (AA 71-187)
SKU: ABIN968495
Availability: OutOfStock

CD40 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 41-CD40 unconjugated

Western blot analysis of CD40 on EB1 cell lysate. (CD40 抗体 (AA 71-187))

Immunofluorescent staining of HeLa cells. (CD40 抗体 (AA 71-187))

Image no. 3 for anti-CD40 (CD40) (AA 71-187) antibody (ABIN968495) (CD40 抗体 (AA 71-187))

Western Blotting (WB) image for anti-CD40 (CD40) (AA 71-187) antibody (ABIN968495) (CD40 抗体 (AA 71-187))

4 images

(3 references)

产品编号 ABIN968495

发货至: 中国

Datasheet as PDF

抗原 See all CD40 抗体

CD40
抗原表位
17

16

15

14

13

13

9

5

5

4

3

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 71-187
适用
180

97

20

20

6

6

4

4

4

4

2

2

2

2

2

1
人
宿主
99

96

43

5

1

1

1
小鼠
Compatible Secondaries
克隆类型
149

90

5
单克隆
标记
118

22

20

17

12

5

4

4

3

3

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This CD40 antibody is un-conjugated
应用范围
143

93

60

48

30

28

20

17

16

14

13

13

5

4

4

4

3

3

3

2

2

2

2

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF)

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human CD40 aa. 71-187

克隆位点

41-CD40

亚型

IgG1

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说明

Related Products: ABIN968584, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Morio, Hanissian, Bacharier, Teraoka, Nonoyama, Seki, Kondo, Nakano, Lee, Geha, Yata: "Ku in the cytoplasm associates with CD40 in human B cells and translocates into the nucleus following incubation with IL-4 and anti-CD40 mAb." in: Immunity, Vol. 11, Issue 3, pp. 339-48, (1999) (PubMed).

Nguyen, Duncan, Mirtsos, Ng, Speiser, Shahinian, Marino, Mak, Ohashi, Yeh: "TRAF2 deficiency results in hyperactivity of certain TNFR1 signals and impairment of CD40-mediated responses." in: Immunity, Vol. 11, Issue 3, pp. 379-89, (1999) (PubMed).

Randall, Heath, Santos-Argumedo, Howard, Weissman, Lund: "Arrest of B lymphocyte terminal differentiation by CD40 signaling: mechanism for lack of antibody-secreting cells in germinal centers." in: Immunity, Vol. 8, Issue 6, pp. 733-42, (1998) (PubMed).
抗原

CD40

别名

CD40 (CD40 产品)

别名

Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody

背景

CD40, a member of the TNF receptor family, contains a cysteine-rich N-terminal domain and a Ser/Thr-rich region preceding the transmembrane domain. On B cells, signaling through CD40 induces cell growth and differentiation, mediates cell survival within the germinal center, and upregulates the expression of costimulatory and adhesion molecules, such as B7.1, B7.2, and ICAM-1. The interaction of CD40 on B cells and CD40L on activated CD4+ T cells is essential for immune functions, such as immuoglobulin class switching. Signal transduction through CD40 pathways involves interaction with proteins such as TRAFs (TRAF2, TRAF3, TRAF5, and TRAF6), Jak 3, and Tyr phosphorylation of proteins, such as Lyn, Syk, PI-3-kinase, STAT3, and STAT5. In TRAF2-deficient mice, CD40-mediated B cell proliferation and NFkappaB activation are defective. Ku70 and Ku80 associate with the membrane-proximal region of CD40 in human primary B cells and the engagement of CD40 leads translocation of Ku proteins to the nucleus. Thus, CD40 interacts with a variety of signal transducers which mediate its role in B cell survival, growth, differentiation, and immunoglobulin class switching.

分子量

44 kDa

途径

NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints