HAP1 抗体 (AA 100-289)
(5 references)-
- 抗原 See all HAP1 抗体
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
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抗原表位
- AA 100-289
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适用
- 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 小鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat HAP1-A aa. 100-289
- 克隆位点
- 1-HAP1
- 亚型
- IgG1
- Top Product
- Discover our top product HAP1 Primary Antibody
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anti-Huntingtin Associated Protein 1 (HAP1) (Internal Region) antibody
Verified HAP1 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 132-328) antibodyHAP1 适用: 小鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 328-580) antibodyHAP1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 1-671) antibodyHAP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (C-Term) antibodyVerified HAP1 适用: 小鼠, 大鼠 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 349-584) antibodyHAP1 适用: 大鼠 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (AA 160-381) antibodyHAP1 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) antibodyHAP1 适用: 大鼠 WB, IHC, IP 宿主: 小鼠 Monoclonal 1B6 unconjugated
anti-Huntingtin Associated Protein 1 (HAP1) (Center) antibodyHAP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968545, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28212-21, (2002) (PubMed).
: "The cellular and subcellular localization of huntingtin-associated protein 1 (HAP1): comparison with huntingtin in rat and human." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 18, Issue 19, pp. 7674-86, (1998) (PubMed).
: "A human HAP1 homologue. Cloning, expression, and interaction with huntingtin." in: The Journal of biological chemistry, Vol. 273, Issue 30, pp. 19220-7, (1998) (PubMed).
: "Huntingtin-associated protein (HAP1): discrete neuronal localizations in the brain resemble those of neuronal nitric oxide synthase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 10, pp. 4839-44, (1996) (PubMed).
: "A huntingtin-associated protein enriched in brain with implications for pathology." in: Nature, Vol. 378, Issue 6555, pp. 398-402, (1995) (PubMed).
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: "Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking." in: The Journal of biological chemistry, Vol. 277, Issue 31, pp. 28212-21, (2002) (PubMed).
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- 抗原
- HAP1 (Huntingtin Associated Protein 1 (HAP1))
- 别名
- HAP1 (HAP1 产品)
- 别名
- HAP2 antibody, HIP5 antibody, HLP antibody, hHLP1 antibody, HAP1-A antibody, HAP1-B antibody, HAP-1 antibody, huntingtin associated protein 1 antibody, huntingtin-associated protein 1 antibody, HAP1 antibody, Hap1 antibody
- 背景
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Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by an expanding polyglutamine repeat in the IT15 or huntingtin gene. The mechanism(s) of pathogenesis are not known and the wide expression of Huntingtin protein does not explain the selective neuropathology of HD. HAP-1 (Huntingtin-associated protein 1), identified by yeast two hybrid screening, interacts with the huntingtin protein. There are two isoforms of rat HAP1 (HAP1-A and HAP1-B) which differ in the length of their C-terminal regions. Both proteins are highly hydrophilic and their binding to the Huntingtin protein is enhanced by the expanded polyglutamine repeat. Human HAP1 shares 62% amino acid identity with HAP1-A. HAP1 is specifically expressed in the CNS where it is restricted to limbic structures, such as amygdala, hypothalamus, bed nucleus of the stria terminalis, and the septal nucleus. The subcellular association of HAP1 with microtubules and many types of membraneous organelles implicates it in vesicular transport. Thus, the specific neural interaction of HAP1 with Huntingtin protein may lead to abnormalities in vesicular transport that cause the neuropathology of HD. This antibody is routinely tested by western blot analysis.
Synonyms: Huntingtin Associated Protein 1 - 分子量
- 85/98 kDa
- 途径
- Cell RedoxHomeostasis, Smooth Muscle Cell Migration, Positive Regulation of Response to DNA Damage Stimulus
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