TIMM23 抗体 (AA 5-126)
(3 references)-
- 抗原 See all TIMM23 抗体
- TIMM23 (Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) (TIMM23))
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抗原表位
- AA 5-126
- 适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TIMM23 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 小鼠, 人
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat Tim23 aa. 5-126
- 克隆位点
- 32-Tim23
- 亚型
- IgG2a
- Top Product
- Discover our top product TIMM23 Primary Antibody
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anti-Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) (TIMM23) (AA 1-209) antibody
TIMM23 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) (TIMM23) (N-Term) antibodyTIMM23 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) (TIMM23) (AA 130-158), (C-Term) antibodyTIMM23 适用: 人 WB 宿主: 兔 Polyclonal RB33814 unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix." in: The EMBO journal, Vol. 18, Issue 13, pp. 3667-75, (1999) (PubMed).
: "The preprotein translocase of the mitochondrial inner membrane: function and evolution." in: Journal of molecular biology, Vol. 286, Issue 1, pp. 105-20, (1999) (PubMed).
: "Characterization of the mitochondrial inner membrane translocase complex: the Tim23p hydrophobic domain interacts with Tim17p but not with other Tim23p molecules." in: Molecular and cellular biology, Vol. 18, Issue 1, pp. 178-87, (1998) (PubMed).
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: "The TIM17.23 preprotein translocase of mitochondria: composition and function in protein transport into the matrix." in: The EMBO journal, Vol. 18, Issue 13, pp. 3667-75, (1999) (PubMed).
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- 抗原
- TIMM23 (Translocase of Inner Mitochondrial Membrane 23 Homolog (Yeast) (TIMM23))
- 别名
- Tim23 (TIMM23 产品)
- 别名
- Tim23 antibody, TIM23 antibody, tim23 antibody, timm23 antibody, timm23b antibody, CHUNP6887 antibody, TIMM23 antibody, translocase of inner mitochondrial membrane 23 antibody, translocase of inner mitochondrial membrane 23 homolog (yeast) antibody, mitochondrial import inner membrane translocase subunit Tim23 antibody, translocase of inner mitochondrial membrane 23 homolog L homeolog antibody, translocase of inner mitochondrial membrane 23 homolog a (yeast) antibody, Timm23 antibody, TIMM23 antibody, LOC101118849 antibody, timm23.L antibody, timm23a antibody, LOC100157391 antibody, LOC486776 antibody
- 背景
- Mitochondria, the site of cellular energy production, must import all proteins necessary for their function. Import is mediated by two mechanisms: the translocase of the outer membrane (Tom) and the translocase of the inner membrane (Tim). Tim23 and Tim17 are integral membrane proteins that associate to form the import channel for mitochondrial preproteins that contain N-terminal hydrophilic sequences. They also associate with Tim44, an adaptor for the membrane binding of mtHsp70, a matrix heat shock protein, which drives the import of the processed preprotein. The N-terminal intermembrane space domain of Tim23 contains a leucine zipper motif and mediates the formation of a Tim23 dimer. As an imported protein passes through the TOM machinery, its N-terminal matrix targeting sequence interacts with the Tim23 dimer. This induces the dissociation of the dimer and initiation of inner membrane translocation of the presequence. In addition to its 9 kDa N-terminal hydrophilic segment, Tim23 contains a 14 kDa hydrophobic domain with four predicted membrane spans. Thus, Tim23 is an important integral membrane component of the mitochondrial protein translocation machinery.
- 分子量
- 23 kDa
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