CG7626 Gene Product From Transcript CG7626-RA (SPT5) (AA 866-985) 抗体
SPT5
适用: 犬, 人, 小鼠, 大鼠
IF, WB
宿主: 小鼠
Monoclonal
17-DSIF
unconjugated
(1 reference)-
- 抗原
- CG7626 Gene Product From Transcript CG7626-RA (SPT5)
- 抗原表位
- AA 866-985
- 适用
- 犬, 人, 小鼠, 大鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunofluorescence (IF), Western Blotting (WB)
- 交叉反应
- 犬, 小鼠, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human DSIF aa. 866-985
- 克隆位点
- 17-DSIF
- 亚型
- IgG1
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- 说明
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Related Products: ABIN968535, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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-
: "Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation." in: Molecular and cellular biology, Vol. 22, Issue 13, pp. 4622-37, (2002) (PubMed).
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: "Phosphorylation of the RNA polymerase II carboxyl-terminal domain by CDK9 is directly responsible for human immunodeficiency virus type 1 Tat-activated transcriptional elongation." in: Molecular and cellular biology, Vol. 22, Issue 13, pp. 4622-37, (2002) (PubMed).
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- 抗原
- CG7626 Gene Product From Transcript CG7626-RA (SPT5)
- 别名
- DSIF
- 背景
- In living systems, the relative amounts of any protein are controlled at many levels. For example, amounts are affected by protein degradation, regulation of the translational rates of polypeptide synthesis (translational regulation), and control of the rates of mRNA synthesis (transcriptional regulation). Transcriptional regulation involves modulation of the rate-limiting enzyme RNA polymerase. DSIF (DRB sensitivity-inducing factor) is a heterodimeric transcription elongation protein. It is composed of a large subunit of 160 kDa and a small subunit of 14 kDa. These large and the small subunits are homologs of the yeast gene products Stp5 and Stp4, respectively. Spt4 and 5 are transcription factors which are critically important for the activity of RNA polymerase. In conjunction with DRB, DSIF attenuates RNA polymerase II elongation steps. However, in limiting amounts of ribonucleotides, DSIF, by itself, stimulates the elongation rate of RNA polymerase II. Thus, the identification of a human regulator for transcriptional elongation will greatly enhance our understanding of this critical step in mammalian gene expression. This antibody is routinely tested by western blot analysis.
- 分子量
- 160 kDa
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