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NCOA3 抗体 (AA 376-389)

Name: NCOA3 抗体 (AA 376-389)
SKU: ABIN968368
Availability: OutOfStock

NCOA3 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 34-AIB unconjugated

Western Blotting (WB) image for anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 376-389) antibody (ABIN968368) (NCOA3 抗体 (AA 376-389))

Western blot analysis of AIB-1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). (NCOA3 抗体 (AA 376-389))

Image no. 3 for anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 376-389) antibody (ABIN968368) (NCOA3 抗体 (AA 376-389))

3 images

(5 references)

产品编号 ABIN968368

发货至: 中国

Datasheet as PDF

抗原 See all NCOA3 抗体

NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))
抗原表位
15

14

9

7

3

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 376-389
适用
61

16

8

5

4

3

2

2

2

1

1

1
人, 小鼠, 大鼠
宿主
55

7

1

1
小鼠
Compatible Secondaries
克隆类型
58

6
单克隆
标记
33

4

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This NCOA3 antibody is un-conjugated
应用范围
38

24

13

13

11

9

5

4

3

3

2

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

交叉反应

小鼠, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human AIB-1 aa. 376-389

克隆位点

34-AIB

亚型

IgG1

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anti-Nuclear Receptor Coactivator 3 (NCOA3) antibody
NCOA3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (Internal Region) antibody
NCOA3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 188-198) antibody
NCOA3 适用: 人, Cow, 犬, Pig, 猴, Bat, Hamster IHC, IHC (p) 宿主: 山羊 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 576-625) antibody
NCOA3 适用: 人, Cow, Pig, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) antibody
NCOA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5H3 unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (pThr24) antibody
NCOA3 适用: 人 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 344-372), (N-Term) antibody
NCOA3 适用: 人 WB 宿主: 兔 Polyclonal RB41497 unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) antibody
NCOA3 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Nuclear Receptor Coactivator 3 (NCOA3) (AA 1-200) antibody
NCOA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2C11B12 unconjugated

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Louie, Yang, Ma, Xu, Zou, Kung, Chen: "Androgen-induced recruitment of RNA polymerase II to a nuclear receptor-p160 coactivator complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2226-30, (2003) (PubMed).

Lauritsen, List, Reiter, Wellstein, Riegel: "A role for TGF-beta in estrogen and retinoid mediated regulation of the nuclear receptor coactivator AIB1 in MCF-7 breast cancer cells." in: Oncogene, Vol. 21, Issue 47, pp. 7147-55, (2002) (PubMed).

Reiter, Wellstein, Riegel: "An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer." in: The Journal of biological chemistry, Vol. 276, Issue 43, pp. 39736-41, (2001) (PubMed).

Eng, Barsalou, Akutsu, Mercier, Zechel, Mader, White: "Different classes of coactivators recognize distinct but overlapping binding sites on the estrogen receptor ligand binding domain." in: The Journal of biological chemistry, Vol. 273, Issue 43, pp. 28371-7, (1998) (PubMed).

Anzick, Kononen, Walker, Azorsa, Tanner, Guan, Sauter, Kallioniemi, Trent, Meltzer: "AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer." in: Science (New York, N.Y.), Vol. 277, Issue 5328, pp. 965-8, (1997) (PubMed).
抗原

NCOA3 (Nuclear Receptor Coactivator 3 (NCOA3))

别名

AIB-1 (NCOA3 产品)

别名

NCOA3 antibody, ACTR antibody, AIB-1 antibody, AIB1 antibody, CAGH16 antibody, CTG26 antibody, KAT13B antibody, RAC3 antibody, SRC-3 antibody, SRC3 antibody, TNRC14 antibody, TNRC16 antibody, TRAM-1 antibody, bHLHe42 antibody, pCIP antibody, 2010305B15Rik antibody, AW321064 antibody, Actr antibody, Aib1 antibody, Rac3 antibody, Src3 antibody, Tram-1 antibody, Tram1 antibody, p/Cip antibody, pCip antibody, actr antibody, aib-1 antibody, aib1 antibody, cagh16 antibody, ctg26 antibody, kat13b antibody, pcip antibody, rac3 antibody, src-3 antibody, src3 antibody, tnrc14 antibody, tnrc16 antibody, tram-1 antibody, xSRC-3 antibody, nuclear receptor coactivator 3 antibody, nuclear receptor coactivator 3 S homeolog antibody, NCOA3 antibody, Ncoa3 antibody, ncoa3.S antibody

背景

Signal transduction via nuclear hormone receptors is important for cell growth and differentiation, development, and homeostasis. Nuclear hormone receptors are ligand-activated transcription factors that modulate target gene expression. These ligand/receptor complexes also interact with transcriptional coactivators which enhance ligand-dependent transcription. Various classes of coactivators have been identified, including SRC-1 and its related proteins, such as TIF-2/GRIP-1, RIP140, AIB-1, and TIF-1alpha and -1beta. AIB-1 (Amplified In Breast cancer-1) is also known as pCIP, RAC3, and TRAM-1. It interacts with estrogen receptor (ER) and is overexpressed in breast cancer biopsies and several breast and ovarian cancer cell lines. Similar to SRC-1 and TIF2, AIB-1 contains a basic helix-loop-helix (bHLH) domain followed by a PAS (Per/Arnt/Sim) region, serine and threonine rich regions, and a charged cluster. In addition, AIB-1 contains three copies of the conserved LXXLL motif which is critical to its interaction with the nuclear receptor. Thus, AIB-1 is a coactivator of nuclear receptors that may participate in the development of steroid-dependent cancers.
Synonyms: Amplified In Breast cancer-1, pCIP, RAC3, TRAM-1

分子量

160 kDa

途径

Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Lipid Metabolism by PPARalpha