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Aurora Kinase B 抗体 (AA 2-124)

Name: Aurora Kinase B 抗体 (AA 2-124)
SKU: ABIN968358
Availability: OutOfStock

AURKB 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 小鼠 Monoclonal 6-AIM unconjugated

Western blot analysis of AIM-1 on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). (Aurora Kinase B 抗体 (AA 2-124))

Image no. 1 for anti-Aurora Kinase B (AURKB) (AA 2-124) antibody (ABIN968358) (Aurora Kinase B 抗体 (AA 2-124))

Immunofluorescence staining of human endothelial cells. (Aurora Kinase B 抗体 (AA 2-124))

3 images

(5 references)

产品编号 ABIN968358

发货至: 中国

Datasheet as PDF

抗原 See all Aurora Kinase B (AURKB) 抗体

Aurora Kinase B (AURKB)
抗原表位
20

19

17

14

10

8

8

7

6

6

5

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 2-124
适用
125

68

35

13

4

4

2

1

1

1

1

1
人, 小鼠, 大鼠
宿主
121

23

3

1
小鼠
Compatible Secondaries
克隆类型
109

40
单克隆
标记
83

11

8

7

5

5

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This Aurora Kinase B antibody is un-conjugated
应用范围
92

66

43

36

17

14

14

13

8

6

4

3

3

3

2

2

1

1
Western Blotting (WB), Immunofluorescence (IF)

交叉反应

人, 小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Rat AIM-1 aa. 2-124

克隆位点

6-AIM

亚型

IgG1

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AURKB 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) (AA 1-90) antibody
AURKB 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 6H7 unconjugated

anti-Aurora Kinase B (AURKB) (AA 6-35) antibody
AURKB 适用: 人, 小鼠, 大鼠, 灵长类 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) antibody
AURKB 适用: 人 WB, ELISA, IHC, IP 宿主: 兔 Monoclonal 4E5 unconjugated Recombinant Antibody

anti-Aurora Kinase B (AURKB) (AA 1-90) antibody
AURKB 适用: 人 WB, ELISA, RNAi 宿主: 小鼠 Monoclonal 6G8 unconjugated

anti-Aurora Kinase B (AURKB) (AA 89-251) antibody
AURKB 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal rAURKB-1592 unconjugated Recombinant Antibody

anti-Aurora Kinase B (AURKB) (pThr232) antibody
AURKB 适用: 人, 小鼠, 大鼠, 猴 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) (AA 1-255) antibody
AURKB 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Aurora Kinase B (AURKB) (AA 89-251) antibody
AURKB 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal AURKB-1592 unconjugated

anti-Aurora Kinase B (AURKB) (pThr232) antibody
AURKB 适用: 人, 小鼠, 大鼠, Cow, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN967389, ABIN968537

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Trinkle-Mulcahy, Andrews, Wickramasinghe, Sleeman, Prescott, Lam, Lyon, Swedlow, Lamond: "Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 107-17, (2003) (PubMed).

Chen, Jin, Tahir, Zhang, Liu, Sarthy, McGonigal, Liu, Rosenberg, Ng: "Survivin enhances Aurora-B kinase activity and localizes Aurora-B in human cells." in: The Journal of biological chemistry, Vol. 278, Issue 1, pp. 486-90, (2002) (PubMed).

Lange, Rebollo, Herold, González: "Cdc37 is essential for chromosome segregation and cytokinesis in higher eukaryotes." in: The EMBO journal, Vol. 21, Issue 20, pp. 5364-74, (2002) (PubMed).

Tatsuka, Katayama, Ota, Tanaka, Odashima, Suzuki, Terada: "Multinuclearity and increased ploidy caused by overexpression of the aurora- and Ipl1-like midbody-associated protein mitotic kinase in human cancer cells." in: Cancer research, Vol. 58, Issue 21, pp. 4811-6, (1998) (PubMed).

Terada, Tatsuka, Suzuki, Yasuda, Fujita, Otsu: "AIM-1: a mammalian midbody-associated protein required for cytokinesis." in: The EMBO journal, Vol. 17, Issue 3, pp. 667-76, (1998) (PubMed).
抗原

Aurora Kinase B (AURKB)

别名

AIM-1 (AURKB 产品)

背景

The mitotic phase of the cell cycle is a complex process that ensures the fidelity of chromosome segregation. During the final stage of mitosis (telophase), segregated chromosomes become less condense and nuclear membranes surround the two sets of daughter chromosomes. Simultaneously, the separation and segregation of the cytoplasm (cytokinesis) ensures complete division and formation of two identical daughter cells. Regulation of cytokinesis is poorly understood and errors in this process can lead to cell death or oncogenesis. The Drosophila serine/threonine protein kinase Aurora and the S. cerevisiae Ipl1 kinase are highly homologous and are required for progression through mitosis. Their mammalian homolog AIM-1 (also known as Aurora and Ipl1-like midbody associated protein) accumulates at the G2/M interface. During late anaphase, AIM-1 is found at the equator of central spindles. However, during telophase and cytokinesis, it is found at the midbody. Although over-expression of a kinase-inactive AIM-1 mutant disrupts formation of the cleavage furrow, nuclear division is unaffected. Thus, it is thought that AIM-1 is essential for cleavage furrowing and the onset of cytokinesis.
Synonyms: Aurora B, Aurora and Ipl1-like midbody associated protein

分子量

41 kDa

途径

TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades