我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

ITGA2 抗体 (AA 42-245)

Name: ITGA2 抗体 (AA 42-245)
SKU: ABIN968317
Availability: OutOfStock

ITGA2 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 2-CD49b unconjugated

Western blot analysis of CD49b (Integrin alpha2) on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2. (ITGA2 抗体 (AA 42-245))

Immunofluorescence staining of WiDr cells (Human colorectal adenocarcinoma, ATCC CCL-218). (ITGA2 抗体 (AA 42-245))

2 images

(4 references)

产品编号 ABIN968317

发货至: 中国

Datasheet as PDF

抗原 See all ITGA2 抗体

ITGA2 (Integrin alpha 2 (ITGA2))
抗原表位
14

8

8

6

5

5

5

5

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 42-245
适用
124

60

22

11

6

6

5

3

3

2

2

2

1

1

1

1
人
宿主
79

44

19

5

5
小鼠
Compatible Secondaries
克隆类型
82

73
单克隆
标记
63

24

17

14

8

4

4

4

3

3

3

3

1

1

1

1

1

1
This ITGA2 antibody is un-conjugated
应用范围
67

63

42

37

14

12

11

11

10

6

5

3

2

2
Western Blotting (WB), Immunofluorescence (IF)

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human VLA-2alpha aa.42-245

克隆位点

2-CD49b

亚型

IgG2a

Top Product

Discover our top product ITGA2 Primary Antibody
anti-Integrin alpha 2 (ITGA2) (AA 30-119) antibody
ITGA2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2B6 unconjugated

anti-Integrin alpha 2 (ITGA2) (AA 994-1132) antibody
ITGA2 适用: 人 FACS, ELISA, ICC 宿主: 小鼠 Monoclonal 5E3A8 unconjugated

anti-Integrin alpha 2 (ITGA2) (AA 170-361) antibody
ITGA2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (Internal Region) antibody
ITGA2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (C-Term) antibody
ITGA2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (AA 678-894) antibody
ITGA2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (AA 74-277) antibody
ITGA2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (AA 188-365) antibody
ITGA2 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) (C-Term) antibody
ITGA2 适用: 人, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha 2 (ITGA2) antibody (FITC)
ITGA2 适用: 人, Non-Human Primate FACS 宿主: 小鼠 Monoclonal AK7 FITC

说明

Related Products: ABIN968535, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Förster, Mäkela, Wärri, Kietz, Becker, Hultenby, Warner, Gustafsson: "Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 24, pp. 15578-83, (2002) (PubMed).

Russell, Tofilon: "Radiation-induced activation of nuclear factor-kappaB involves selective degradation of plasma membrane-associated I(kappa)B(alpha)." in: Molecular biology of the cell, Vol. 13, Issue 10, pp. 3431-40, (2002) (PubMed).

Emsley, King, Bergelson, Liddington: "Crystal structure of the I domain from integrin alpha2beta1." in: The Journal of biological chemistry, Vol. 272, Issue 45, pp. 28512-7, (1997) (PubMed).

Wu, Santoro: "Complex patterns of expression suggest extensive roles for the alpha 2 beta 1 integrin in murine development." in: Developmental dynamics : an official publication of the American Association of Anatomists, Vol. 199, Issue 4, pp. 292-314, (1994) (PubMed).
抗原

ITGA2 (Integrin alpha 2 (ITGA2))

别名

CD49b (ITGA2 产品)

别名

BR antibody, CD49B antibody, GPIa antibody, HPA-5 antibody, VLA-2 antibody, VLAA2 antibody, DX5 antibody, integrin subunit alpha 2 antibody, integrin alpha 2 antibody, ITGA2 antibody, Itga2 antibody

背景

Integrins are a family of dimeric proteins that mediate cell-to-cell and extracellular matrix adhesion. They consist of a large alpha chain that is non-covalently associated with a smaller beta chain which is used to define integrin subfamilies. These molecules exhibit a wide range of expression throughout development and adulthood. VLA-2 (very late antigen), a member of the integrin superfamily, was identified on activated T cells, but has since been reported to be on various cell types. VLA-2 is reported to be a heterodimer of integrin alpha2 (CD49b) and integrin beta1 (CD29) subunits. The alpha2 chain contains a large extracellular domain, a transmembrane domain, and a short cytoplasmic tail. VLA-2 functions as a collagen receptor on platelets and fibroblasts, as well as a collagen and laminin receptor on endothelial and epithelial cells. On activated T cells, VLA-2, like LFA-1, exhibits increased number and affinity of ligand binding. Interactions of these molecules with their extracellular matrix ligands is important for directing effector T cells to their target tissues and to provide co-stimulatory signals. Thus, VLA-2 not only plays an important role in cellular adhesion, but may function in intracellular signal transmission. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alpha2, VLA-2alpha

分子量

150 kDa

途径

CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex