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PRKACA 抗体 (AA 18-347)

PRKACA 适用: 人, 小鼠, 大鼠, 犬 WB, IF 宿主: 小鼠 Monoclonal 5B unconjugated
产品编号 ABIN968292
发货至: 中国
  • 抗原 See all PRKACA 抗体
    PRKACA (Protein Kinase A, alpha (PRKACA))
    抗原表位
    • 15
    • 9
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 18-347
    适用
    • 53
    • 36
    • 13
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬
    宿主
    • 57
    • 9
    • 2
    • 1
    小鼠
    克隆类型
    • 61
    • 8
    单克隆
    标记
    • 38
    • 5
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PRKACA antibody is un-conjugated
    应用范围
    • 52
    • 31
    • 17
    • 13
    • 13
    • 10
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    交叉反应
    犬, 大鼠, 小鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human PKA[Calpha] subunit aa. 18-347
    克隆位点
    5B
    亚型
    IgG2b
    Top Product
    Discover our top product PRKACA Primary Antibody
  • 说明

    Related Products: ABIN968535, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • DeSouza, Reiken, Ondrias, Yang, Matkovich, Marks: "Protein kinase A and two phosphatases are components of the inositol 1,4,5-trisphosphate receptor macromolecular signaling complex." in: The Journal of biological chemistry, Vol. 277, Issue 42, pp. 39397-400, (2002) (PubMed).

    Chen, Yu, Lee, Chiang, Chao, Huang, Chiong, Huang, Lai, Yang-Yen, Yen: "CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal." in: Molecular and cellular biology, Vol. 21, Issue 14, pp. 4636-46, (2001) (PubMed).

    Orellana, Marfella-Scivittaro: "Distinctive cyclic AMP-dependent protein kinase subunit localization is associated with cyst formation and loss of tubulogenic capacity in Madin-Darby canine kidney cell clones." in: The Journal of biological chemistry, Vol. 275, Issue 28, pp. 21233-40, (2000) (PubMed).

    Westphal, Soderling, Alto, Langeberg, Scott: "Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multi-kinase scaffold." in: The EMBO journal, Vol. 19, Issue 17, pp. 4589-600, (2000) (PubMed).

    Taylor, Buechler, Yonemoto: "cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes." in: Annual review of biochemistry, Vol. 59, pp. 971-1005, (1990) (PubMed).

  • 抗原
    PRKACA (Protein Kinase A, alpha (PRKACA))
    别名
    PKA C (PRKACA 产品)
    别名
    PKACA antibody, Calpha antibody, Cs-PKA antibody, PKCA1 antibody, PKA antibody, PKCD antibody, Pkaca antibody, zgc:158799 antibody, protein kinase cAMP-activated catalytic subunit alpha antibody, protein kinase, cAMP dependent, catalytic, alpha antibody, cAMP-dependent protein kinase catalytic subunit antibody, protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a antibody, PRKACA antibody, Prkaca antibody, kin-1 antibody, prkacaa antibody
    背景
    CAMP-dependent Protein Kinase (PKA) is composed of two distinct subunits: catalytic (C) and regulatory (R). Four regulatory subunits have been identified: RIalpha, RIbeta, RIIalpha, and RIIbeta. These subunits define type I and II cAMP-dependent protein kinases. Following binding of cAMP, the regulatory subunits dissociate from the catalytic subunits, rendering the enzyme active. Type I and type II holoenzymes have three potential C subunits (Calpha, Cbeta, or Cgamma). Type II PKA can be distinguished by autophosphorylation of the R-subunits, while type I PKA binds Mg/ATP with high affinity. The levels of expression of the different subunits vary according to cell and tissue type.
    分子量
    40 kDa
    途径
    NF-kappaB Signaling, Hedgehog Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Thyroid Hormone Synthesis, Carbohydrate Homeostasis, Myometrial Relaxation and Contraction, M Phase, G-protein mediated Events, Signaling Events mediated by VEGFR1 and VEGFR2, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, Lipid Metabolism, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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