我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

P4HB 抗体 (AA 109-214)

Name: P4HB 抗体 (AA 109-214)
SKU: ABIN968268
Availability: OutOfStock

This anti-P4HB antibody is a 小鼠单克隆 antibody detecting P4HB in WB 和 IF. Suitable for 人, 小鼠, 大鼠和犬. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of PDI on HCT-8 cell lysate. (P4HB 抗体 (AA 109-214))

Image no. 2 for anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 109-214) antibody (ABIN968268) (P4HB 抗体 (AA 109-214))

Western Blotting (WB) image for anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 109-214) antibody (ABIN968268) (P4HB 抗体 (AA 109-214))

3 images

(5 references)

产品编号 ABIN968268

发货至: 中国

Quick Overview for P4HB 抗体 (AA 109-214) (ABIN968268)

抗原

See all P4HB 抗体

P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

适用

人, 小鼠, 大鼠, 犬

宿主

小鼠

克隆类型

单克隆

标记

This P4HB antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

34-PDI

Discover our top product P4HB Primary Antibody

抗原表位
19

18

15

13

10

6

4

4

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
AA 109-214

交叉反应

人, 犬, 大鼠, 小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Bovine PDI aa. 109-214

亚型

IgG1
anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 1-508) antibody
P4HB 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) antibody
P4HB 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) antibody
P4HB 适用: 人 WB, IF, ICC, IHC (p), IEM 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (N-Term) antibody
P4HB 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 329-508) antibody
P4HB 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 1-508) antibody
P4HB 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 409-509) antibody
P4HB 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (C-Term) antibody
P4HB 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, Pig, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 499-509) antibody
P4HB 适用: 人, 小鼠, 大鼠, Hamster, Cow, 犬, 猴, 豚鼠, Pig, 绵羊, 兔, 非洲爪蟾, 小鸡 WB, IHC, ICC, IHC (p) 宿主: 小鼠 Monoclonal unconjugated

anti-Prolyl 4-Hydroxylase, beta Polypeptide (P4HB) (AA 409-509) antibody (HRP)
P4HB 适用: 大鼠 WB, IHC, IP, IF, ICC 宿主: 兔 Polyclonal HRP

说明

Related Products: ABIN968551, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Jenne, Frey, Brugger, Wieland: "Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway." in: The Journal of biological chemistry, Vol. 277, Issue 48, pp. 46504-11, (2002) (PubMed).

Schlegel, Arvan, Lisanti: "Caveolin-1 binding to endoplasmic reticulum membranes and entry into the regulated secretory pathway are regulated by serine phosphorylation. Protein sorting at the level of the endoplasmic reticulum." in: The Journal of biological chemistry, Vol. 276, Issue 6, pp. 4398-408, (2001) (PubMed).

Weissman, Kim: "Efficient catalysis of disulphide bond rearrangements by protein disulphide isomerase." in: Nature, Vol. 365, Issue 6442, pp. 185-8, (1993) (PubMed).

Wetterau, Combs, Spinner, Joiner: "Protein disulfide isomerase is a component of the microsomal triglyceride transfer protein complex." in: The Journal of biological chemistry, Vol. 265, Issue 17, pp. 9800-7, (1990) (PubMed).

Yamauchi, Yamamoto, Hayashi, Koya, Takikawa, Toyoshima, Horiuchi: "Sequence of membrane-associated thyroid hormone binding protein from bovine liver: its identity with protein disulphide isomerase." in: Biochemical and biophysical research communications, Vol. 146, Issue 3, pp. 1485-92, (1987) (PubMed).
抗原

P4HB (Prolyl 4-Hydroxylase, beta Polypeptide (P4HB))

别名

PDI

背景

The ER is the site of translation of membrane and secretory proteins. Following synthesis, it shuttles these proteins through a contiguous membrane system to their appropriate destinations. Protein disulfide isomerase (PDI) is an abundant, multifunctional, eukaryotic protein. Although it exhibits ubiquitous expression, it is primarily located in the ER lumen. Here, it functions to catalyze the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configurations. This role in rearrangement has lead to the classification of PDI as a chaperone. Although protein folding occurs in its absence, PDI may be essential for it to proceed at a physiological relevant rate. In addition, PDI is the beta-subunit of prolyl 4- hydroxylase and is a component of the triglyceride transfer complex. PDI is retained in the ER lumen via its C-terminal -KDEL sequence. Via this sequence, it is continuously recycled back to the ER from other membranous compartments. Thus, PDI is a diverse protein whose primary function may be to correct disulfide bonding and, thus, ensure the most stable conformation of newly synthesized proteins.

分子量

55 kDa

途径

Maintenance of Protein Location, Cell RedoxHomeostasis, Lipid Metabolism