SRP54 抗体 (AA 262-476)
(2 references)-
- 抗原 See all SRP54 抗体
- SRP54 (Signal Recognition Particle 54kDa (SRP54))
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抗原表位
- AA 262-476
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适用
- 人, 小鼠, 大鼠, 犬, Frog
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SRP54 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 交叉反应
- 犬, 大鼠, 小鼠, Frog
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human SRP54 aa. 262-476
- 克隆位点
- 30-SRP54
- 亚型
- IgG1
- Top Product
- Discover our top product SRP54 Primary Antibody
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anti-Signal Recognition Particle 54kDa (SRP54) antibody
SRP54 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 1-504) antibodySRP54 适用: 人 ELISA, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 1-100) antibodySRP54 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2G7 unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 346-374) antibodySRP54 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 196-455) antibodySRP54 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) antibodySRP54 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 391-440) antibodySRP54 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (AA 182-231) antibodySRP54 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (Middle Region) antibodySRP54 适用: 人, 小鼠, 大鼠, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Recognition Particle 54kDa (SRP54) (Middle Region) antibodySRP54 适用: 人, 小鼠, 大鼠, 犬, Cow, 豚鼠, 马, 兔, 斑马鱼, 山羊 WB 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum." in: Cell, Vol. 89, Issue 5, pp. 703-13, (1997) (PubMed).
: "Modulation of the signal recognition particle 54-kDa subunit (SRP54) in rat preosteoblasts by the extracellular matrix." in: The Journal of biological chemistry, Vol. 270, Issue 36, pp. 20891-4, (1995) (PubMed).
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: "Empty site forms of the SRP54 and SR alpha GTPases mediate targeting of ribosome-nascent chain complexes to the endoplasmic reticulum." in: Cell, Vol. 89, Issue 5, pp. 703-13, (1997) (PubMed).
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- 抗原
- SRP54 (Signal Recognition Particle 54kDa (SRP54))
- 别名
- SRP54 (SRP54 产品)
- 别名
- Srp54k antibody, zgc:55842 antibody, zgc:85713 antibody, SRP54 antibody, signal recognition particle 54 antibody, signal recognition particle protein antibody, signal recognition particle subunit Srp54 antibody, signal recognition particle antibody, family with sequence similarity 177 member A1 antibody, signal recognition particle 54kDa S homeolog antibody, signal recognition particle 54kDa antibody, SRP54 antibody, srp54 antibody, SSO_RS04840 antibody, MA_RS23935 antibody, AF_RS03170 antibody, PAB_RS02540 antibody, MSP_RS07670 antibody, RCI_RS04175 antibody, TGAM_RS09885 antibody, MTBMA_RS08340 antibody, FAM177A1 antibody, srp54.S antibody, Srp54 antibody
- 背景
- Ribosomes that exist freely in the cytosol or those attached to the ER are intrinsically the same in their translational properties. ER-bound ribosomes are responsible for the production of secretory proteins and integral ER, Golgi, lysosomal, and plasma membrane spanning proteins. Such proteins contain signal sequences that direct their synthesis to the ER membrane. As the nascent polypeptide emerges from the ribosome, a signal recognition particle (SRP) binds to the signal sequence and serves to couple the ribosome to the protein-translocating machinery in the ER membrane. Although the SRP is a 325 kDa ribonucleoprotein, its 54 kDa subunit (SRP54) mediates interaction with, and targeting of, the nascent protein to the ER. Via its C-terminal M-domain, SRP54 associates with the nascent protein and inhibits its elongation. This complex binds to the SRP receptor on the ER, the ribosome is delivered to the translocation machinery, SRP is released, and elongation resumes. Targeting and insertion are tightly coupled to a GTPase cycle that involves SRP54 and SRP receptor. Although the mechanisms are unclear, release of SRP from the ER-bound complex requires GTP hydrolysis.
- 分子量
- 54 kDa
- 途径
- SARS-CoV-2 Protein Interactome
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