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N-Cadherin 抗体 (AA 802-819)

Name: N-Cadherin 抗体 (AA 802-819)
SKU: ABIN968250
Availability: OutOfStock

CDH2 适用: 人, 小鼠, 大鼠, 小鸡 WB, IF, IP 宿主: 小鼠 Monoclonal 32-N unconjugated

Western blot analysis of N-Cadherin on HeLa lysate. (N-Cadherin 抗体 (AA 802-819))

Immunofluorescent staining of 293 cells with anti-N-Cadherin. (N-Cadherin 抗体 (AA 802-819))

Image no. 3 for anti-Cadherin 2 (CDH2) (AA 802-819) antibody (ABIN968250) (N-Cadherin 抗体 (AA 802-819))

Western Blotting (WB) image for anti-Cadherin 2 (CDH2) (AA 802-819) antibody (ABIN968250) (N-Cadherin 抗体 (AA 802-819))

4 images

(5 references)

产品编号 ABIN968250

发货至: 中国

Datasheet as PDF

抗原 See all N-Cadherin (CDH2) 抗体

N-Cadherin (CDH2) (Cadherin 2 (CDH2))
抗原表位
19

15

15

8

6

5

4

3

3

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 802-819
适用
145

96

68

21

16

14

8

4

3

3

3

3

2

2

2

2

2

1

1

1
人, 小鼠, 大鼠, 小鸡
宿主
98

54

4

2

2
小鼠
Compatible Secondaries
克隆类型
90

69

1
单克隆
标记
79

15

5

4

4

4

4

4

4

4

4

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This N-Cadherin antibody is un-conjugated
应用范围
110

50

41

39

25

23

18

14

13

13

9

9

4

2

2

1
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)

交叉反应

人, 大鼠, 小鸡

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Mouse N-Cadherin aa. 802-819

克隆位点

32-N

亚型

IgG1

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CDH2 适用: 人 WB, IHC, IF, FACS, IHC (f) 宿主: 小鼠 Monoclonal 8C11 unconjugated

说明

Related Products: ABIN967389, ABIN968535

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Izawa, Nishizawa, Ohtakara, Inagaki: "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses." in: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 5345-50, (2002) (PubMed).

Nürnberger, Bacallao, Phillips: "Inversin forms a complex with catenins and N-cadherin in polarized epithelial cells." in: Molecular biology of the cell, Vol. 13, Issue 9, pp. 3096-106, (2002) (PubMed).

Bhowmick, Ghiassi, Bakin, Aakre, Lundquist, Engel, Arteaga, Moses: "Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism." in: Molecular biology of the cell, Vol. 12, Issue 1, pp. 27-36, (2001) (PubMed).

Cowin: "Unraveling the cytoplasmic interactions of the cadherin superfamily." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 23, pp. 10759-61, (1994) (PubMed).

Miyatani, Shimamura, Hatta, Nagafuchi, Nose, Matsunaga, Hatta, Takeichi: "Neural cadherin: role in selective cell-cell adhesion." in: Science (New York, N.Y.), Vol. 245, Issue 4918, pp. 631-5, (1989) (PubMed).
抗原

N-Cadherin (CDH2) (Cadherin 2 (CDH2))

别名

N-Cadherin (CDH2 产品)

背景

Cadherins are a family of Ca2+-dependent intercellular adhesion molecules that play a central role in controlling morphogenetic movements during development. Their function is regulated by association with the actin cytoskeleton by a complex of cytoplasmic proteins called the catenins (alpha, beta, gamma). Members of the cadherin family include P-cadherin, E-cadherin (uvomorulin), N-cadherin (neural cadherin), R-cadherin, cadherin 5, L-CAM, and EP-cadherin. N-cadherin mRNA is found at elevated levels in brain and heart and at a much lower level in liver. Mechanisms such as mRNA expression, cytokine modulation, and protease-mediated turnover modulate N-cadherin protein levels during development. In addition, N-cadherin function is indirectly regulated by endogenous kinases and phosphatases. Tyrosine phosphorylation of beta-catenin complexed with N-cadherin results in dissociation of N-cadherin from actin. However, N-cadherin also interacts with a PTP1B-like phosphatase that dephosphorylates beta-catenin and promotes N-cadherin/actin association. Thus, N-cadherin is an integral adhesion molecule whose function is regulated by protein-protein interactions and phosphorylation/dephosphorylation events.

分子量

130 kDa

途径

Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Synaptic Membrane