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PAX5 抗体 (AA 151-306)

Name: PAX5 抗体 (AA 151-306)
SKU: ABIN968220
Availability: OutOfStock

PAX5 适用: 人, 小鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 24-Pax unconjugated

Western blot analysis of Pax-5 on mouse spleen lysate. (PAX5 抗体 (AA 151-306))

Pax-5 staining on paraformaldehyde-fixed SW-13 cells. (PAX5 抗体 (AA 151-306))

Pax-5 (clone 24) staining on human tonsil. (PAX5 抗体 (AA 151-306))

IHC (p)

3 images

(5 references)

产品编号 ABIN968220

发货至: 中国

Datasheet as PDF

抗原 See all PAX5 抗体

PAX5 (Paired Box 5 (PAX5))
抗原表位
15

9

8

7

7

6

6

5

5

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
AA 151-306
适用
102

48

7

3

3

2

2

2

2

2

1

1

1

1
人, 小鼠
宿主
83

15

3

1
小鼠
Compatible Secondaries
克隆类型
74

28
单克隆
标记
55

8

7

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This PAX5 antibody is un-conjugated
应用范围
62

46

27

16

15

14

13

5

4

4

3

2

2

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

交叉反应

小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human Pax-5 aa. 151-306

克隆位点

24-Pax

亚型

IgG1

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说明

Related Products: ABIN968544, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Klein, Tu, Stolovitzky, Keller, Haddad, Miljkovic, Cattoretti, Califano, Dalla-Favera: "Transcriptional analysis of the B cell germinal center reaction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 5, pp. 2639-44, (2003) (PubMed).

Hertel, Zhou, Hamilton-Dutoit, Junker: "Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma." in: Oncogene, Vol. 21, Issue 32, pp. 4908-20, (2002) (PubMed).

Foss, Reusch, Demel, Lenz, Anagnostopoulos, Hummel, Stein: "Frequent expression of the B-cell-specific activator protein in Reed-Sternberg cells of classical Hodgkin's disease provides further evidence for its B-cell origin." in: Blood, Vol. 94, Issue 9, pp. 3108-13, (1999) (PubMed).

Zwollo, Arrieta, Ede, Molinder, Desiderio, Pollock: "The Pax-5 gene is alternatively spliced during B-cell development." in: The Journal of biological chemistry, Vol. 272, Issue 15, pp. 10160-8, (1997) (PubMed).

Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: "Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis." in: Genes & development, Vol. 6, Issue 9, pp. 1589-607, (1992) (PubMed).
抗原

PAX5 (Paired Box 5 (PAX5))

别名

Pax-5 (PAX5 产品)

别名

PAX5 antibody, BSAP antibody, Pax-5 antibody, pax5-a antibody, RGD1565236 antibody, EBB-1 antibody, KLP antibody, Pax[Zf-b] antibody, noi antibody, pax2.1 antibody, pax2a antibody, paxzf-b antibody, paired box 5 antibody, paired box 5 L homeolog antibody, PAX5 antibody, pax5.L antibody, Pax5 antibody, pax5 antibody

背景

There are at least nine members of the paired box (Pax) gene family whose protein products are transcription factors involved in development. The conserved paired box DNA-binding domain is found in the N-terminal region of Pax proteins. An octomer and homeodomain sequence are conserved in the center of the proteins. The Ser/Thr/Pro-rich region in the C-terminal portion contains a conserved 100 amino acid transactivating domain. One of the best studied Pax family members, Pax 5, is a B cell specific activator protein (BSAP). In the early stages of B cell development, Pax-5 influences the expression of several B-cell-specific genes, such as CD19 and CD20. Pax-5 is expressed primarily in pro-, pre-, and mature B cells, but not in plasma cells. Interestingly, Pax-5 mRNA is transiently detected in the mesencephalon and spinal cord during embryogenesis. Expression then shifts to the fetal liver and correlates with the onset of B lymphopoiesis. Pax-5 has been found to be important in both B cell and nervous system development. This antibody is routinely tested by western blot analysis.

分子量

50 kDa