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UBE2L3 抗体 (AA 15-133)

UBE2L3 适用: 人, 小鼠, 大鼠, 犬, Frog WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 20-UbcH7 unconjugated
产品编号 ABIN968215
发货至: 中国
  • 抗原 See all UBE2L3 抗体
    UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
    抗原表位
    • 15
    • 14
    • 13
    • 8
    • 7
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 15-133
    适用
    • 62
    • 14
    • 11
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    人, 小鼠, 大鼠, 犬, Frog
    宿主
    • 60
    • 1
    • 1
    小鼠
    克隆类型
    • 61
    • 1
    单克隆
    标记
    • 29
    • 6
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UBE2L3 antibody is un-conjugated
    应用范围
    • 57
    • 32
    • 20
    • 13
    • 13
    • 13
    • 7
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    小鼠, 大鼠, 犬, Frog
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human UbcH7 aa. 15-133
    克隆位点
    20-UbcH7
    亚型
    IgG1
    Top Product
    Discover our top product UBE2L3 Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Hagglund, Van Sant, Lopez, Roizman: "Herpes simplex virus 1-infected cell protein 0 contains two E3 ubiquitin ligase sites specific for different E2 ubiquitin-conjugating enzymes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 2, pp. 631-6, (2002) (PubMed).

    Shimura, Schlossmacher, Hattori, Frosch, Trockenbacher, Schneider, Mizuno, Kosik, Selkoe: "Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease." in: Science (New York, N.Y.), Vol. 293, Issue 5528, pp. 263-9, (2001) (PubMed).

  • 抗原
    UBE2L3 (Ubiquitin-Conjugating Enzyme E2L 3 (UBE2L3))
    别名
    UbcH7 (UBE2L3 产品)
    别名
    E2-F1 antibody, L-UBC antibody, UBCH7 antibody, UbcM4 antibody, C79827 antibody, Ubce7 antibody, ube2l3 antibody, wu:fc22h11 antibody, zgc:86727 antibody, UBE2L3 antibody, ube2l3l antibody, wu:fb38h03 antibody, ubiquitin conjugating enzyme E2 L3 antibody, ubiquitin-conjugating enzyme E2L 3 antibody, ubiquitin-conjugating enzyme E2L 3a antibody, ubiquitin conjugating enzyme E2 L3 S homeolog antibody, ubiquitin-conjugating enzyme E2L 3b antibody, UBE2L3 antibody, Ube2l3 antibody, ube2l3a antibody, ube2l3.S antibody, ube2l3b antibody
    背景
    Progression of the mammalian cell cycle is regulated mainly by phosphorylation/dephosphorylation and synthesis/degradation of many key proteins. Ubiquitin, a soluble protein of 76 amino acids, is enzymatically attached to an epsilon-NH2-Lys in a target protein. Ubiquitination is a hallmark for rapid protein degradation of the target protein in the proteosome-a cytoplasmic complex of proteases. Several human homologs of the yeast ubiquitin-conjugating enzymes (Ubc) have been identified and found involved in critical processes such as cell cycle progression and apoptosis. UbcH7 was characterized as an E6-AP-interacting protein required for the ubiquitination of p53. E6-AP is the ubiquitin ligase used as bait in the search for interacting proteins required for the proper ubiquitination of cellular targets. UbcH7 interacts with the C-terminal region of E6-AP named the hect domain. Therefore, UbcH7 is another protein, like Ubc9, involved in the degradation and regulation of critical proteins in the cell cycle. This antibody is routinely tested by western blot analysis.
    Synonyms: Ubiquitin Conjugating Enzyme H7
    分子量
    17-18 kDa
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