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CASK 抗体 (AA 353-486)

Name: CASK 抗体 (AA 353-486)
SKU: ABIN968174
Availability: OutOfStock

CASK 适用: 人, 小鼠, 大鼠, 犬, Frog WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 7-CASK unconjugated

Western blot analysis of CASK on a rat cerebrum lysate. (CASK 抗体 (AA 353-486))

Image no. 2 for anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 353-486) antibody (ABIN968174) (CASK 抗体 (AA 353-486))

2 images

(5 references)

产品编号 ABIN968174

发货至: 中国

Datasheet as PDF

抗原 See all CASK 抗体

CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))
抗原表位
15

8

5

3

3

1

1

1

1

1

1

1

1
AA 353-486

适用

人, 小鼠, 大鼠, 犬, Frog
宿主
54

2
小鼠
Compatible Secondaries
克隆类型
54

2
单克隆
标记
20

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This CASK antibody is un-conjugated
应用范围
22

16

14

13

13

8

6

3

2

2

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

交叉反应

小鼠, 人, 犬, Frog

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Rat CASK aa. 353-486

克隆位点

7-CASK

亚型

IgG1

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CASK 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 262-291) antibody
CASK 适用: 人 WB 宿主: 兔 Polyclonal RB15769 unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 470-760) antibody
CASK 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) antibody
CASK 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (N-Term) antibody
CASK 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 651-750) antibody
CASK 适用: 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 564-596), (C-Term) antibody
CASK 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1248 unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 589-616) antibody
CASK 适用: 大鼠 WB 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) (AA 1-337), (AA 318-415) antibody
CASK 适用: 小鼠, 大鼠, Hamster WB 宿主: 兔 Polyclonal unconjugated

anti-Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK) antibody
CASK 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968545, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Fallon, Moreau, Croft, Labib, Gu, Fon: "Parkin and CASK/LIN-2 associate via a PDZ-mediated interaction and are co-localized in lipid rafts and postsynaptic densities in brain." in: The Journal of biological chemistry, Vol. 277, Issue 1, pp. 486-91, (2002) (PubMed).

Biederer, Sudhof: "CASK and protein 4.1 support F-actin nucleation on neurexins." in: The Journal of biological chemistry, Vol. 276, Issue 51, pp. 47869-76, (2001) (PubMed).

Borg, Lõpez-Figueroa, de Taddèo-Borg, Kroon, Turner, Watson, Margolis: "Molecular analysis of the X11-mLin-2/CASK complex in brain." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 4, pp. 1307-16, (1999) (PubMed).

Irie, Hata, Takeuchi, Ichtchenko, Toyoda, Hirao, Takai, Rosahl, Südhof: "Binding of neuroligins to PSD-95." in: Science (New York, N.Y.), Vol. 277, Issue 5331, pp. 1511-5, (1997) (PubMed).

Hata, Butz, Südhof: "CASK: a novel dlg/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 16, Issue 8, pp. 2488-94, (1996) (PubMed).
抗原

CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

别名

CASK (CASK 产品)

背景

CASK is a recently identified cytosolic protein kinase with homology to the Ca2+/CaM-dependent kinases and the synaptic associated proteins SAPs/PSDs. Like the SAPs, CASK contains a PDZ domain, an SH3 region, and a guanylate kinase domain. However, unlike the rest of the PDZ protein family, the amino terminus of CASK has significant homology with the Ca2+/Calmodulin-dependent kinases. Although widely expressed, CASK is highly enriched in the synaptic plasma membrane where it associates with neurexins, the neuronal cell surface proteins. Neurexins are a complex family of surface proteins that act as receptors for a number of venoms and toxins and regulate the clustering of several ion channels at the synapse. In addition, neurexins bind heterotypically to neuroligins, therefore adjoining different cell types. Neuroligins bind intracellularly to PSD95 and related proteins, whereas neurexins bind to CASK through their C-terminal region and at CASK's PDZ domain. The interaction of neurexins and CASK at the outside of the cell may modulate CASK's activity and trigger an intracellular signaling cascade.

分子量

120 kDa

途径

Synaptic Vesicle Exocytosis