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CENPF 抗体 (AA 209-381)

CENPF 适用: 人 IHC, WB, IP, IF 宿主: 小鼠 Monoclonal 11-Mitosin unconjugated
产品编号 ABIN968167
发货至: 中国
  • 抗原 See all CENPF 抗体
    CENPF (Centromere Protein F (CENPF))
    抗原表位
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 209-381
    适用
    • 23
    • 2
    • 1
    • 1
    宿主
    • 21
    • 1
    • 1
    小鼠
    克隆类型
    • 22
    • 1
    单克隆
    标记
    • 16
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This CENPF antibody is un-conjugated
    应用范围
    • 9
    • 7
    • 6
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human Mitosin aa. 209-381
    克隆位点
    11-Mitosin
    亚型
    IgG1
    Top Product
    Discover our top product CENPF Primary Antibody
  • 说明

    Related Products: ABIN968537, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Trinkle-Mulcahy, Andrews, Wickramasinghe, Sleeman, Prescott, Lam, Lyon, Swedlow, Lamond: "Time-lapse imaging reveals dynamic relocalization of PP1gamma throughout the mammalian cell cycle." in: Molecular biology of the cell, Vol. 14, Issue 1, pp. 107-17, (2003) (PubMed).

    Landberg, Erlanson, Roos, Tan, Casiano: "Nuclear autoantigen p330d/CENP-F: a marker for cell proliferation in human malignancies." in: Cytometry, Vol. 25, Issue 1, pp. 90-8, (1997) (PubMed).

    Casiano, Humbel, Peebles, Covini, Tan: "Autoimmunity to the cell cycle-dependent centromere protein p330d/CENP-F in disorders associated with cell proliferation." in: Journal of autoimmunity, Vol. 8, Issue 4, pp. 575-86, (1996) (PubMed).

    Zhu, Mancini, Chang, Liu, Chen, Shan, Jones, Yang-Feng, Lee: "Characterization of a novel 350-kilodalton nuclear phosphoprotein that is specifically involved in mitotic-phase progression." in: Molecular and cellular biology, Vol. 15, Issue 9, pp. 5017-29, (1995) (PubMed).

    Rattner, Rao, Fritzler, Valencia, Yen: "CENP-F is a .ca 400 kDa kinetochore protein that exhibits a cell-cycle dependent localization." in: Cell motility and the cytoskeleton, Vol. 26, Issue 3, pp. 214-26, (1994) (PubMed).

  • 抗原
    CENPF (Centromere Protein F (CENPF))
    别名
    Mitosin (CENPF 产品)
    别名
    LOC100222985 antibody, 6530404A22Rik antibody, AI325968 antibody, CENF antibody, Lek1 antibody, PRO1779 antibody, mitosin antibody, im:7140452 antibody, im:7144238 antibody, im:7154719 antibody, im:7156761 antibody, si:ch211-152h14.2 antibody, hcp-1 antibody, CMF1 antibody, centromere protein F antibody, CENPF antibody, Cenpf antibody, cenpf antibody
    背景
    Mitosin, a nuclear proetin of 3113 amino acids, contains a pair of tandem repeats and seven leucine repeats. In vitro, Mitosin directly interacts with the retinoblastoma protein, Rb. Mitosin is expressed throughout the cell cycle, with levels being lowest during G1, and it localizes at the kinetochore during the mitotic phase. The subcellular redistribution of Mitosin to the kinetochore is linked to its phosphorylation. Its expression is linked to patients with autoimmune diseases characterized by abnormal cell proliferation. Ectopic expression of a truncated version of Mitosin blocks the progression of the cell cycle. This suggests that the protein has an important role during cell proliferation. Because of similarities in subcellular localization and expression, Mitosin and the autoantigen p300/CENP-F, which is also linked to a multitude of autoimmune disorders, are probably the same protein.
    分子量
    357 kDa
    途径
    Chromatin Binding, M Phase, SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection
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