Dystrobrevin (AA 249-403) 抗体
适用: 小鼠, 兔, 大鼠
IF, IP, IHC, WB
宿主: 小鼠
Monoclonal
23-Dystrobrevin
unconjugated
(1 reference)-
- 抗原
- Dystrobrevin
- 抗原表位
- AA 249-403
- 适用
- 小鼠, 兔, 大鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
- 交叉反应
- 大鼠, 兔
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse Dystrobrevin aa. 249-403
- 克隆位点
- 23-Dystrobrevin
- 亚型
- IgG1
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- 说明
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Related Products: ABIN968546, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein." in: The Journal of biological chemistry, Vol. 271, Issue 13, pp. 7802-10, (1996) (PubMed).
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: "Isoform diversity of dystrobrevin, the murine 87-kDa postsynaptic protein." in: The Journal of biological chemistry, Vol. 271, Issue 13, pp. 7802-10, (1996) (PubMed).
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- 抗原
- Dystrobrevin
- 背景
- Acetylcholine receptor clustering is considered an early event and a marker for synaptogenesis between a motor neuron and a muscle fiber. This process is mediated by the extracellular protein Agrin which binds to alpha and beta Dystroglycan, previously discovered as Dystrobrevin- associated proteins. Dystrobrevin binds to the actin cytoskeleton by its N-terminal domain, thus providing the link between the actin cytoskeleton and receptor clustering. In Torpedo electric organ, Dystrobrevin is a prominent phosphotyrosine-containing protein. Murine Dystrobrevins comprise a family of four related proteins (1-4) with similar function, generated by alternative splicing. Dystrobrevin-1 is 688 amino acids and has an apparent mobility of 87kDa. Dystrobrevin-2 shares almost identical sequence with Dystrobrevin-1 in the first 500 amino acids and has an apparent mobility of 59kDa.
- 分子量
- 87 kDa
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