ROCK2 抗体 (AA 567-718)
(5 references)-
- 抗原 See all ROCK2 抗体
- ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))
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抗原表位
- AA 567-718
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ROCK2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 交叉反应
- 小鼠, 犬, 人
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat ROKalpha aa. 567-718
- 克隆位点
- 21-ROCK
- 亚型
- IgG1
- Top Product
- Discover our top product ROCK2 Primary Antibody
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anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 904-1140) antibody
ROCK2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibodyROCK2 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibodyKO Validated ROCK2 适用: 人 WB, IP, IF, IHC (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1001-1300) antibodyROCK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1109-1388) antibodyROCK2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 652-923) antibodyROCK2 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1388) antibodyROCK2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2A4 unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) antibodyROCK2 适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 10E1 unconjugated Recombinant Antibody
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (N-Term) antibodyROCK2 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2) (AA 1279-1389) antibodyROCK2 适用: 人 WB, ELISA, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1E12 unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 6214-22, (2002) (PubMed).
: "RhoA-mediated Ca2+ sensitization in erectile function." in: The Journal of biological chemistry, Vol. 277, Issue 34, pp. 30614-21, (2002) (PubMed).
: "The functional role of rho and rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 167, Issue 8, pp. 4609-15, (2001) (PubMed).
: "Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility." in: The EMBO journal, Vol. 20, Issue 4, pp. 755-66, (2001) (PubMed).
: "A novel serine/threonine kinase binding the Ras-related RhoA GTPase which translocates the kinase to peripheral membranes." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29051-4, (1996) (PubMed).
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: "Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 6214-22, (2002) (PubMed).
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- 抗原
- ROCK2 (rho-Associated, Coiled-Coil Containing Protein Kinase 2 (ROCK2))
- 别名
- ROCK-II (ROCK2 产品)
- 背景
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Activity of the GTP-binding proteins is regulated by GAPs, that accelerate binding, and GTPases, that enhance the rate of GTP hydrolysis (Ras, Rho, cdc42Hs, and Rac). The isoforms of Rho, a small GTP-binding protein, regulate cellular processes such as the formation of the stress fibers, lamelipodia, and filopodia. ROKalpha (RhoA-binding kinase) is a Ser/Thr protein kinase that interects with the GTP-binding form of RhoA. Like RhoA, ROKalpha localizes at the cellular margins and colocalizes with acti filaments. The ROKalpha gene encodes a protein of 1302 amino acids with homology to the human myotonic kinase. Although ROKalpha binds to GTP-RhoA, it is not yet clear whether this interaction induces the kinase activity of ROKalpha.
Synonyms: ROKalpha - 分子量
- 180 kDa
- 途径
- Microtubule Dynamics, WNT signaling, Tube Formation
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