IQGAP1 抗体 (AA 1348-1490)
(5 references)-
- 抗原 See all IQGAP1 抗体
- IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))
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抗原表位
- AA 1348-1490
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This IQGAP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
- 交叉反应
- 小鼠, 大鼠, 犬
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human IQGAP1 aa. 1348-1490
- 克隆位点
- 24-IQGAP1
- 亚型
- IgG1
- Top Product
- Discover our top product IQGAP1 Primary Antibody
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anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 611-710) antibody
IQGAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C5 unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 500-750) antibodyIQGAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 1451-1550) antibodyIQGAP1 适用: 人, 大鼠, 兔 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) antibodyIQGAP1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibodyIQGAP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibodyIQGAP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) antibodyIQGAP1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibodyIQGAP1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 793-808), (Intracellular) antibodyIQGAP1 适用: 人, 小鼠, 大鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (Internal Region) antibodyVerified IQGAP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968536, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49998-50007, (2002) (PubMed).
: "The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33081-91, (2002) (PubMed).
: "Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1." in: Molecular and cellular biology, Vol. 20, Issue 2, pp. 697-701, (2000) (PubMed).
: "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs." in: The EMBO journal, Vol. 15, Issue 12, pp. 2997-3005, (1996) (PubMed).
: "Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1." in: The Journal of biological chemistry, Vol. 271, Issue 38, pp. 23363-7, (1996) (PubMed).
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: "The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49998-50007, (2002) (PubMed).
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- 抗原
- IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))
- 别名
- IQGAP1 (IQGAP1 产品)
- 别名
- HUMORFA01 antibody, SAR1 antibody, p195 antibody, AA682088 antibody, D7Ertd237e antibody, D7Ertd257e antibody, mKIAA0051 antibody, IQ motif containing GTPase activating protein 1 antibody, IQGAP1 antibody, Iqgap1 antibody
- 背景
- GTPases (Ras, Rho, cdc42Hs, and rac) modulate various cellular functions such as cytoskeletal architecture, growth, motility, and gene expression. The activity of the GTP-binding proteins is regulated by factors that accelerate GTP-binding (GAPs) and proteins that enhance the rate of GTP hydrolysis (GTPases). IQGAP1 is Ras-GAP related protein that contains a WW domain that binds poly-proline regions, a calponin-homology domain (CHD), an IQ domain of unconventional myosins, and a C-terminal GAP-related domain (GRD). IQGAP1 co-immunoprecipitates with cdc42 and calmodulin, and colocalizes with cdc42Hs at the leading edges of the plasma membrane and at the cell-cell junctions. IQGAP1 may interact with both cadherins and catenins leading to dissociation of these proteins from sites of cell adhesion. Thus, IQGAP1 may be a Rac1 and Cdc42 effector that negatively regulates cadherin-mediated cell junctions.
- 分子量
- 195 kDa
- 途径
- Signaling Events mediated by VEGFR1 and VEGFR2
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