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beta Arrestin 1 抗体 (AA 262-409)

Name: beta Arrestin 1 抗体 (AA 262-409)
SKU: ABIN968033
Availability: OutOfStock

ARRB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 10-Beta unconjugated

Western blot analysis of beta-Arrestin on a mouse macrophage lysate. (beta Arrestin 1 抗体 (AA 262-409))

Image no. 2 for anti-Arrestin, beta 1 (ARRB1) (AA 262-409) antibody (ABIN968033) (beta Arrestin 1 抗体 (AA 262-409))

2 images

(5 references)

产品编号 ABIN968033

发货至: 中国

Datasheet as PDF

抗原 See all beta Arrestin 1 (ARRB1) 抗体

beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))
抗原表位
19

12

8

7

5

4

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 262-409
适用
73

46

32

6

3

3

2

2

2

1

1

1

1
人, 小鼠, 大鼠
宿主
79

9

1
小鼠
Compatible Secondaries
克隆类型
73

16
单克隆
标记
52

5

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This beta Arrestin 1 antibody is un-conjugated
应用范围
68

34

32

26

17

14

13

12

8

7

3

1

1

1

1
Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

交叉反应

小鼠, 人

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Rat beta-Arrestin1 aa. 262-409

克隆位点

10-Beta

亚型

IgG1

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anti-Arrestin, beta 1 (ARRB1) (AA 3-246) antibody
ARRB1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) (AA 169-418) antibody
ARRB1 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) antibody
ARRB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IP, FACS, ICC 宿主: 兔 Monoclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) (AA 336-363), (C-Term) antibody
ARRB1 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB31615 unconjugated

anti-Arrestin, beta 1 (ARRB1) (AA 1-260) antibody
ARRB1 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) antibody
ARRB1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) (AA 369-418) antibody
ARRB1 适用: 人 WB, IHC, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) (AA 343-371), (C-Term) antibody
ARRB1 适用: 人 WB, IF, IHC (p), FACS, EIA 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) antibody
ARRB1 适用: 人, 小鼠, 大鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Arrestin, beta 1 (ARRB1) (Ser157) antibody
ARRB1 适用: 人, 猴 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968555, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Dalle, Imamura, Rose, Worrall, Ugi, Hupfeld, Olefsky: "Insulin induces heterologous desensitization of G-protein-coupled receptor and insulin-like growth factor I signaling by downregulating beta-arrestin-1." in: Molecular and cellular biology, Vol. 22, Issue 17, pp. 6272-85, (2002) (PubMed).

Imamura, Huang, Dalle, Ugi, Usui, Luttrell, Miller, Lefkowitz, Olefsky: "beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport." in: The Journal of biological chemistry, Vol. 276, Issue 47, pp. 43663-7, (2001) (PubMed).

DeFea, Zalevsky, Thoma, Déry, Mullins, Bunnett: "beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2." in: The Journal of cell biology, Vol. 148, Issue 6, pp. 1267-81, (2000) (PubMed).

Gurevich, Dion, Onorato, Ptasienski, Kim, Sterne-Marr, Hosey, Benovic: "Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors." in: The Journal of biological chemistry, Vol. 270, Issue 2, pp. 720-31, (1995) (PubMed).

Attramadal, Arriza, Aoki, Dawson, Codina, Kwatra, Snyder, Caron, Lefkowitz: "Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family." in: The Journal of biological chemistry, Vol. 267, Issue 25, pp. 17882-90, (1992) (PubMed).
抗原

beta Arrestin 1 (ARRB1) (Arrestin, beta 1 (ARRB1))

别名

beta-Arrestin1 (ARRB1 产品)

别名

arrb1 antibody, MGC83787 antibody, arb1 antibody, arr1 antibody, barr1 antibody, betaarr1 antibody, 1200006I17Rik antibody, AW208571 antibody, G430100A01Rik antibody, ARB1 antibody, ARR1 antibody, BARRES antibody, arrestin beta 1 antibody, arrestin, beta 1 antibody, arrestin beta 1 L homeolog antibody, beta-arrestin 1 antibody, putative beta-arrestin 1 antibody, ARRB1 antibody, arrb1 antibody, arrb1.L antibody, CpipJ_CPIJ016988 antibody, CpipJ_CPIJ017114 antibody, Smp_122900 antibody, Smp_126080 antibody, Smp_176980 antibody, Smp_152290 antibody, Arrb1 antibody

背景

Beta-Arrestins were discovered due to their ability to modulate interactions between the phosphorylated beta2-Adrenergic receptors and G proteins. This modulation results in diminished beta2-Adrenergic receptor function, also known as desensitization. Because CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are the only stereoisomers degraded by peroxisomal alpha-oxidation. Interestingly, AMACR mutations have been linked to some sensory motor neuropathies where accumulation of fatty acids and AMACR deficiencies correlate with pathogenesis. AMACR contains an N-terminal region required for mitochondrial localization, and a C-terminal peroxisomal targeting signal type 1 (PTS). AMACR mRNA is expressed preferarrestins are found at the synaptic terminals, they may provide a termination mechanism that allows the neurons to regain their original polarization and respond to a new neurotransmitter stimulus. The C-terminal region of arrestins is involved in selecting the phosphorylated and activated adrenergic receptors. The beta-Arrestin1 gene encodes a protein of 418 amino acids with an approximate molecular weight of 55kDa. beta-Arrestin1 protein is highly homologous to the 45kDa beta-Arrestin2. Both proteins are widely expressed, but are especially abundant in the central nervous system.
This antibody is routinely tested by western blot analysis of AMACR enzymatic activity found in the mitochondria relative to the peroxisomes differs depending on the species. Thus, AMACR is an enzyme critical for fatty acid degradation, and bile formation.

分子量

55 kDa

途径

Positive Regulation of Peptide Hormone Secretion, Nuclear Hormone Receptor Binding, cAMP Metabolic Process, Myometrial Relaxation and Contraction, Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction