HCLS1 抗体 (AA 17-190)
(3 references)-
- 抗原 See all HCLS1 抗体
- HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
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抗原表位
- AA 17-190
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This HCLS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human HS1 aa. 17-190
- 克隆位点
- 9-HS1
- 亚型
- IgG1
- Top Product
- Discover our top product HCLS1 Primary Antibody
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anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibody
HCLS1 适用: 人 WB, ELISA, IHC (p), PLA, RNAi 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (N-Term) antibodyHCLS1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 266-355) antibodyHCLS1 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 2A9 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 161-260) antibodyHCLS1 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 1-280) antibodyHCLS1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (C-Term) antibodyHCLS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 28-77) antibodyHCLS1 适用: 人, 小鼠, 大鼠, 兔, Cow, 犬, 马, 豚鼠, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (AA 362-391), (C-Term) antibodyHCLS1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB34076 unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (C-Term) antibodyHCLS1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1) (pTyr397) antibodyHCLS1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968536, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7302-6, (1995) (PubMed).
: "LckBP1, a proline-rich protein expressed in haematopoietic lineage cells, directly associates with the SH3 domain of protein tyrosine kinase p56lck." in: The EMBO journal, Vol. 14, Issue 14, pp. 3403-14, (1995) (PubMed).
: "Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 90, Issue 8, pp. 3631-5, (1993) (PubMed).
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: "Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 16, pp. 7302-6, (1995) (PubMed).
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- 抗原
- HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1 (HCLS1))
- 别名
- HS1 (HCLS1 产品)
- 别名
- CTTNL antibody, HS1 antibody, AW213261 antibody, HCLS1 antibody, hcls1 antibody, si:dkey-9a20.6 antibody, wu:fk96b08 antibody, zgc:154014 antibody, hematopoietic cell-specific Lyn substrate 1 antibody, hematopoietic cell specific Lyn substrate 1 antibody, hematopoietic lineage cell-specific protein-like antibody, HCLS1 antibody, Hcls1 antibody, LOC100223649 antibody, hcls1 antibody
- 背景
- HS1 (lck-binding protein 1 (lckBP1)) is a protein of 486 amino acids with homology to cytoplasmic tyrosine kinases. The protein contains an SH3 domain and two proline-rich regions, that may be the binding site for lck. Co- mmunoprecipitation experiments demonstrated a tight association between HS1 and lck. The SH3 domain of lck is necessary for this interaction. In addition, HS1 contains tandem repeat sequence of seven amino acids which is a substrate for the tyrosine kinase src. This sequence is also found in the protein cortactin. Therefore, HS1, like cortactin, may be an important adaptor that is critical for the regulation of cellular tyrosine kinases. This antibody is routinely tested by western blot analysis.
- 分子量
- 75 kDa
- 途径
- Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Maintenance of Protein Location
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