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MVP 抗体 (AA 403-592)

MVP 适用: 人, 兔, Cow, 犬 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 42-LRP unconjugated
产品编号 ABIN968013
发货至: 中国
  • 抗原 See all MVP 抗体
    MVP (Major Vault Protein (MVP))
    抗原表位
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 403-592
    适用
    • 90
    • 28
    • 26
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 兔, Cow, 犬
    宿主
    • 57
    • 35
    • 1
    小鼠
    克隆类型
    • 47
    • 46
    单克隆
    标记
    • 54
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    This MVP antibody is un-conjugated
    应用范围
    • 48
    • 35
    • 28
    • 27
    • 24
    • 16
    • 9
    • 8
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    牛, 犬, 兔
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human LRP aa. 403-592
    克隆位点
    42-LRP
    亚型
    IgG1
    Top Product
    Discover our top product MVP Primary Antibody
  • 说明

    Related Products: ABIN967389, ABIN968536

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Papura: "Managed care policy regarding OMT reimbursement illogical." in: The Journal of the American Osteopathic Association, Vol. 102, Issue 2, pp. 66, (2002) (PubMed).

    Rybarova, Batekova, Hodorova, Mirossay, Kluchova, Bobrov, Kocisova: "Immunohistochemical detection of LRP protein in the normal human lung." in: Bratislavské lekárske listy, Vol. 102, Issue 2, pp. 66-72, (2001) (PubMed).

    List, Spier, Grogan, Johnson, Roe, Greer, Wolff, Broxterman, Scheffer, Scheper, Dalton: "Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia." in: Blood, Vol. 87, Issue 6, pp. 2464-9, (1996) (PubMed).

    Kickhoefer, Rome: "The sequence of a cDNA encoding the major vault protein from Rattus norvegicus." in: Gene, Vol. 151, Issue 1-2, pp. 257-60, (1995) (PubMed).

    Scheffer, Wijngaard, Flens, Izquierdo, Slovak, Pinedo, Meijer, Clevers, Scheper: "The drug resistance-related protein LRP is the human major vault protein." in: Nature medicine, Vol. 1, Issue 6, pp. 578-82, (1995) (PubMed).

  • 抗原
    MVP (Major Vault Protein (MVP))
    别名
    LRP (MVP 产品)
    别名
    LRP antibody, VAULT1 antibody, 2310009M24Rik antibody, cb771 antibody, wu:fb52b05 antibody, wu:fc02g01 antibody, mvp antibody, MGC145641 antibody, Tb05.45E22.810 antibody, major vault protein antibody, major vault protein L homeolog antibody, putative major vault protein antibody, MVP antibody, Mvp antibody, mvp antibody, mvp.L antibody, Tc00.1047053510353.10 antibody, Tb927.5.4460 antibody, Tb10.70.0520 antibody, Tb10.70.5840 antibody, LMJF_05_0060 antibody
    背景
    Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.
    分子量
    110 kDa
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