Neuronal Pentraxin (AA 137-312) 抗体
适用: 人, 大鼠
IF, IP, IHC, WB
宿主: 小鼠
Monoclonal
22-Neuronal Pentraxin
unconjugated
(2 references)-
- 抗原
- Neuronal Pentraxin
- 抗原表位
- AA 137-312
- 适用
- 人, 大鼠
- 宿主
- 小鼠
- 克隆类型
- 单克隆
- 应用范围
- Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
- 交叉反应
- 人
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Rat Neuronal Pentraxin aa. 137-312
- 克隆位点
- 22-Neuronal Pentraxin
- 亚型
- IgG1
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20°C.
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: "Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 796-803, (2001) (PubMed).
: "Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system." in: Neuron, Vol. 14, Issue 3, pp. 519-26, (1995) (PubMed).
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: "Overexpression of neuronal pentraxin 1 is involved in neuronal death evoked by low K(+) in cerebellar granule cells." in: The Journal of biological chemistry, Vol. 276, Issue 1, pp. 796-803, (2001) (PubMed).
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- 抗原
- Neuronal Pentraxin
- 背景
- Neuronal pentraxin (NP) is a potential receptor for the snake venom toxin, taipoxin. The highest levels of NP mRNA are found in the cerebellum and the CA3 region of the hippocampus. More specifically, NP mRNA is expressed at high levels in Purkinje and granule neurons of the cerebellum and CA3 neurons of the hippocampus. Moderate levels are present in neurons of the hilus, dentate gyrus, CA1, cerebral cortex, medial habenula, anterior hypothalamic nuclei, olfactory cortex, and inferior olivary nuclei. NP mRNA is not expressed in glia of white or gray matter. It is thought that NP serves as a receptor for taipoxin and, after binding, NP-taipoxin is taken into presynaptic terminals. Alternatively, the binding of taipoxin by NP may represent a nonspecific mechanism to sequester toxins from synapses.
- 分子量
- 47 kDa
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