SOS1 抗体 (AA 1-109)
(5 references)-
- 抗原 See all SOS1 抗体
- SOS1 (Son of Sevenless Homolog 1 (SOS1))
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抗原表位
- AA 1-109
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适用
- 人, 小鼠, 大鼠, 犬
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SOS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC)
- 交叉反应
- 大鼠, 犬, 人
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Mouse mSos1 aa. 1-109
- 克隆位点
- 25-SOS1
- 亚型
- IgG1
- Top Product
- Discover our top product SOS1 Primary Antibody
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anti-Son of Sevenless Homolog 1 (SOS1) (AA 1140-1281) antibody
SOS1 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 ELISA, PLA 宿主: 小鼠 Monoclonal 4C1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal SOS-01 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) antibodySOS1 适用: 人, 小鼠 WB, IF, EIA 宿主: 小鼠 Monoclonal SOS-1 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 934-962) antibodySOS1 适用: 人 WB 宿主: 兔 Polyclonal RB23356 unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 313-420) antibodySOS1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 353-402) antibodySOS1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Son of Sevenless Homolog 1 (SOS1) (AA 1034-1333) antibodySOS1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968539, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, (2002) (PubMed).
: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." in: Blood, Vol. 98, Issue 6, pp. 1773-81, (2001) (PubMed).
: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, (2000) (PubMed).
: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." in: Cell, Vol. 73, Issue 3, pp. 611-20, (1993) (PubMed).
: "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." in: Nature, Vol. 363, Issue 6424, pp. 45-51, (1993) (PubMed).
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: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, (2002) (PubMed).
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- 抗原
- SOS1 (Son of Sevenless Homolog 1 (SOS1))
- 别名
- Sos1 (SOS1 产品)
- 物质类
- Viral Protein
- 背景
- The Sos (son of sevenless) gene was originally identified in Drosophila, and two mammalian homologues (mSos1 and mSos2) were isolated from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both mSos1 and mSos2 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues, hSos1 and hSos2 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170 kDa, presumably due to a high proline content. The mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras .
- 分子量
- 170 kDa
- 途径
- RTK signaling, TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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