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IFNGR1 抗体

IFNGR1 适用: 小鼠 FACS, IP 宿主: Armenian Hamster Monoclonal 2E2 unconjugated
产品编号 ABIN967652
发货至: 中国
  • 抗原 See all IFNGR1 抗体
    IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
    适用
    • 58
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    小鼠
    宿主
    • 56
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    Armenian Hamster
    克隆类型
    • 61
    • 13
    • 1
    单克隆
    标记
    • 43
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    This IFNGR1 antibody is un-conjugated
    应用范围
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    Flow Cytometry (FACS), Immunoprecipitation (IP)
    品牌
    BD Pharmingen™
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Purified preparation of soluble recombinant mouse IFN-gammaRalpha chain protein
    克隆位点
    2E2
    亚型
    IgG1 kappa
    Top Product
    Discover our top product IFNGR1 Primary Antibody
  • 应用备注
    Immunofluorescent Staining and Flow Cytometric Analysis: The purified form of 2E2 can be used for the immunofluorescent staining (Less or equal than 1 µg antibody/10e6 cells) and flow cytometric analysis of normal mouse cells or cell lines to measure their expressed levels of IFN-gammaRalpha. An appropriate purified immunoglobulin isotype control is A19-3. A three-layer staining protocol is recommended for maximizing the detection IFN-gammaRalpha chains expressed by cells as detailed in the figure legend.
    2E2 is a nonblocking antibody that can be used for the unobstructed immunofluorescent staining and flow cytometric analysis of cells in systems where the ligand (i.e., IFN-gamma) for IFN-gamma receptors is present. Immunoprecipitation: The 2E2 antibody has been reported to be useful for the immunoprecipitation of IFN-gammaRalpha chains from lysates of cloned mouse T cells.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    0.5 mg/mL
    缓冲液
    Aqueous buffered solution containing ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
    储存方法
    Store undiluted at 4° C.
  • Bach, Szabo, Dighe, Ashkenazi, Aguet, Murphy, Schreiber: "Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets." in: Science (New York, N.Y.), Vol. 270, Issue 5239, pp. 1215-8, (1996) (PubMed).

  • 抗原
    IFNGR1 (Interferon gamma Receptor 1 (IFNGR1))
    别名
    CD119 (IFNGR1 产品)
    别名
    CD119 antibody, IFNGR antibody, IFN-gammaR antibody, Ifgr antibody, Ifngr antibody, Nktar antibody, IFNGR1 antibody, MGC129098 antibody, ifngr1 antibody, MGC194858 antibody, MGC194873 antibody, zgc:194858 antibody, cd119 antibody, ifngr antibody, DKFZp469K1232 antibody, interferon gamma receptor 1 antibody, cytokine receptor family member B17 antibody, IFNGR1 antibody, Ifngr1 antibody, crfb17 antibody, ifngr1 antibody
    背景
    The 2E2 antibody recognizes the extracellular region of the 90 kDa alpha chain subunit of the mouse interferon-gamma receptor (IFN-gammaRalpha, aka, CD119). The functionally active-form of the mouse IFN-gamma receptor consists of two (or more) subunits, with IFN-gammaRalpha responsible for IFN-gamma binding and both the IFN-gammaRalpha and IFN-gammaRbeta chains required for the transduction of biologic responses. IFN-gammaRalpha is expressed by a variety of cell lines and normal mouse cells (except mature erythrocytes) including T cells, B cells, NK cells, monocytes, neutrophils, fibroblasts, epithelial and endothelial cells. The 2E2 antibody is a non-neutralizing antibody, it does not block the binding of IFN-gamma to its receptor. The immunogen used to generate this hybridoma was a purified preparation of soluble recombinant mouse IFN-gammaRalpha chain protein.
    Synonyms: IFN-gamma Receptor alpha chain
    途径
    Interferon-gamma Pathway
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