TRAF2 抗体 (AA 93-199)
(7 references)-
- 抗原 See all TRAF2 抗体
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
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抗原表位
- AA 93-199
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This TRAF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human TRAF2 aa. 93-199
- 克隆位点
- C90-481
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product TRAF2 Primary Antibody
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anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 1-300) antibody
TRAF2 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 238-491) antibodyTRAF2 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (C-Term) antibodyVerified TRAF2 适用: 人, 小鼠 WB, ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 39-188) antibodyTRAF2 适用: 人 ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 5C2C3 unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) antibodyTRAF2 适用: 人 WB, ELISA, IHC, IP, FACS 宿主: 兔 Monoclonal 9A5 unconjugated Recombinant Antibody
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 39-188) antibodyTRAF2 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4A12D9 unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 401-501) antibodyTRAF2 适用: 人 WB, ELISA, FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 147-281) antibodyTRAF2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (AA 1-501) antibodyTRAF2 适用: 人 WB, ELISA, PLA 宿主: 小鼠 Monoclonal 4C11 unconjugated
anti-TNF Receptor-Associated Factor 2 (TRAF2) (C-Term) antibodyTRAF2 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Applications include western blot analysis (1-2 µg/ml). Human cell lines including Jurkat T cells (ATCC TIB-152), 293 adenovirus-transformed kidney cells (ATCC CRL-1573) and Daudi Burkitt lymphoma cells (ATCC CCL-213) are recommended as positive controls.
- 说明
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Related Products: ABIN967389, ABIN968537
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Translocation of TRAF proteins regulates apoptotic threshold of cells." in: Biochemical and biophysical research communications, Vol. 272, Issue 3, pp. 936-45, (2000) (PubMed).
: "Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death." in: Genes & development, Vol. 12, Issue 18, pp. 2821-30, (1998) (PubMed).
: "The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 24, pp. 13973-8, (1997) (PubMed).
: "CD30 induction of human immunodeficiency virus gene transcription is mediated by TRAF2." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 4, pp. 1390-5, (1997) (PubMed).
: "Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice." in: Immunity, Vol. 7, Issue 5, pp. 715-25, (1997) (PubMed).
: "TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways." in: Cell, Vol. 84, Issue 2, pp. 299-308, (1996) (PubMed).
: "TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40." in: Science (New York, N.Y.), Vol. 269, Issue 5229, pp. 1424-7, (1995) (PubMed).
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: "Translocation of TRAF proteins regulates apoptotic threshold of cells." in: Biochemical and biophysical research communications, Vol. 272, Issue 3, pp. 936-45, (2000) (PubMed).
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- 抗原
- TRAF2 (TNF Receptor-Associated Factor 2 (TRAF2))
- 别名
- TRAF2 (TRAF2 产品)
- 别名
- MGC:45012 antibody, TRAP antibody, TRAP3 antibody, TANK antibody, AI325259 antibody, TNF-receptor-associated factor 2 antibody, conjugal transfer protein TraF antibody, TNF receptor associated factor 2 antibody, TNF receptor-associated factor 2 antibody, Tnf receptor-associated factor 2 antibody, LOC661716 antibody, traF2 antibody, TRAF2 antibody, Traf2 antibody
- 背景
- TRAFs (TNF receptor associated factors) are signal transducing molecules which participate in forming TNF/Nerve Growth Factor receptor-associated signalling complexes. TRAF proteins share a novel C-terminal homology region, the TRAF” domain, a coiled-coiled region and the majority have Zinc/RING finger motifs. At least six TRAF proteins (TRAFs 1-6) have been identified. These proteins are cytoplasmic adapters, they bind to cytoplasmic domains of various receptors and can function to recruit other proteins to a signaling complex thereby promoting intracellular signal transduction. Specifically, TRAF2 has been shown to interact with the following surface receptors: TNFRII, CD27, CD30, CD40, 4-1BB, Ox40, HVEM/ATAR and LMP-1. TRAF2 has also been shown to associate with intracellular proteins, including TRADD, FADD, I-TRAF/TANK, TRIP, A20, c-IAP1 and 2, Casper, RIP and NIK. Thus, the interaction of TRAF2 with these various receptors and intracellular proteins plays an important role modulating downstream events which can result in inducing cell death or keeping cells alive. For example, cells deficient in TRAF2 demonstrated increased sensitivity to TNF-induced cell death, but a decrease in TNF-induced JNK activation, and little change on NF-kB activation. TRAF2 is detected at ~ 53 kDa in western blot analysis. The C90-481 antibody reacts with human TRAF2. A synthetic protein freagment corresponding to amino acids 93-199 of human TRAF2 was used as immunogen.
- 分子量
- 53 kDa
- 途径
- NF-kappaB Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity, Hepatitis C, Unfolded Protein Response, S100 Proteins
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