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Ezrin 抗体 (pThr567)

Name: Ezrin 抗体 (pThr567)
SKU: ABIN967590
Availability: OutOfStock

EZR 适用: 人, 小鼠, 大鼠 WB, IHC (f) 宿主: 小鼠 Monoclonal J37-954-281-307 unconjugated

Western blot analysis of Ezrin (pT567) in human epidermis. (Ezrin 抗体 (pThr567))

Ezrin (pT567) staining on human breast cancer. (Ezrin 抗体 (pThr567))

IHC (p)

2 images

(3 references)

产品编号 ABIN967590

发货至: 中国

Datasheet as PDF

抗原 See all Ezrin (EZR) 抗体

Ezrin (EZR)
抗原表位
28

16

10

9

9

9

6

5

5

4

4

3

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pThr567
适用
140

79

69

9

8

6

6

4

4

3

3

1

1

1

1
人, 小鼠, 大鼠
宿主
130

9

3

2
小鼠
Compatible Secondaries
克隆类型
124

19
单克隆
标记
90

6

4

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1
This Ezrin antibody is un-conjugated
应用范围
117

55

26

17

16

13

13

13

11

8

3

2

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))

品牌

BD Pharmingen™

交叉反应（详细）

Predicted: Mouse, Rat

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Phosphorylated Ezrin Peptide

克隆位点

J37-954-281-307

亚型

IgG1 kappa

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说明

Related Products: ABIN967389, ABIN968533, ABIN968534, ABIN968057

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Gautreau, Louvard, Arpin: "Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane." in: The Journal of cell biology, Vol. 150, Issue 1, pp. 193-203, (2000) (PubMed).

Tran Quang, Gautreau, Arpin, Treisman: "Ezrin function is required for ROCK-mediated fibroblast transformation by the Net and Dbl oncogenes." in: The EMBO journal, Vol. 19, Issue 17, pp. 4565-76, (2000) (PubMed).

Gautreau, Poullet, Louvard, Arpin: "Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 13, pp. 7300-5, (1999) (PubMed).
抗原

Ezrin (EZR)

别名

Ezrin (EZR 产品)

背景

Ezrin is a member of the ERM (Ezrin-Radixin-Moesin) family of proteins that can function as a crosslinker between the actin cytoskeleton and the plasma membrane of the cell. Phosphorylation of threonine residues (Thr567 on Ezrin, Thr564 on Radixin and Thr558 on Moesin) has been reported to occur with stimulation of growth factors and is important for cytoskeletal rearrangements. Phosphorylation of Thr567 at the C-terminal F actin-binding domain has been reported to activate the conversion of Ezrin from a dormant soluble form in the cytosol to a membrane- and actin-binding conformation.
In addition to its reactivity to the human species, the peptide used to generate this antibody is either identical or has homology to analogous regions of mouse and rat Ezrin, Radixin and Moesin. The J37-954.281.307 monoclonal antibody has been reported to recognize phosphorylated T567 on active Ezrin in addition to crossreacting on phosphorylated T564 on Radixin and phosphorylated T558 on Moesin.

分子量

75-80 kDa

途径

Maintenance of Protein Location