Androgen Receptor 抗体
(5 references)-
- 抗原 See all Androgen Receptor (AR) 抗体
- Androgen Receptor (AR)
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Androgen Receptor antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Purified human androgen receptor recombinant protein
- 克隆位点
- G122-434
- 亚型
- IgG2a
- Top Product
- Discover our top product AR Primary Antibody
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anti-Androgen Receptor (AR) antibody
AR 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (N-Term) antibodyAR 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) antibodyAR 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 2H8 unconjugated
anti-Androgen Receptor (AR) antibodyAR 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 491-679) antibodyAR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D4 unconjugated
anti-Androgen Receptor (AR) (AA 221-320) antibodyAR 适用: 人 WB, ELISA, IHC (p), PLA 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Androgen Receptor (AR) (N-Term) antibodyVerified AR 适用: 人 WB, ELISA, IHC, IF, ChIP 宿主: 山羊 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 15-246) antibodyAR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (AA 365-392) antibodyAR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Androgen Receptor (AR) (pSer578) antibodyAR 适用: 人, 小鼠, 大鼠 IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Applications include western blot analysis (1-2 µg/ml), immunoprecipitation (1-2 µg/ml) and immunohistochemical staining of frozen tissue sections (titrate between 5 and 20 µg/ml). LNCaP prostate carcinoma cells (ATCC CRL 1740) are suggested as positive controls.
- 说明
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Related Products: ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C.
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: "Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells." in: Cancer research, Vol. 59, Issue 23, pp. 5892-5, (2000) (PubMed).
: "A nonsteroidal anti-inflammatory drug, flufenamic acid, inhibits the expression of the androgen receptor in LNCaP cells." in: Endocrinology, Vol. 140, Issue 11, pp. 5451-4, (1999) (PubMed).
: "Characterization of human androgen receptor overexpressed in the baculovirus system." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 13, pp. 5946-50, (1992) (PubMed).
: "The steroid receptor superfamily: mechanisms of diversity." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 5, Issue 15, pp. 3092-9, (1992) (PubMed).
: "Androgen receptor gene mutations in human prostate cancer." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 14, pp. 6319-23, (1992) (PubMed).
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: "Resveratrol inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells." in: Cancer research, Vol. 59, Issue 23, pp. 5892-5, (2000) (PubMed).
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- 抗原
- Androgen Receptor (AR)
- 别名
- Androgen Receptor (AR 产品)
- 别名
- AIS antibody, DHTR antibody, HUMARA antibody, HYSP1 antibody, KD antibody, NR3C4 antibody, SBMA antibody, SMAX1 antibody, TFM antibody, AW320017 antibody, Tfm antibody, Andr antibody, AR antibody, androgen receptor antibody, AR antibody, Ar antibody, ar antibody
- 背景
- The androgen receptor (AR) mediating androgen effects is a member of the steroid and thyroid hormone receptor gene superfamily encoding liganddependent nuclear transcription factors. They can be divided into three main domains, an N-terminal domain which modulates transcription efficiency, a central DNA domain which binds to a target gene hormone response element, and a C-terminal hormone binding domain. Androgens are necessary for normal male development and function. They exert their effects on target tissue through binding to the AR, followed by association of the AR complex with specific binding sites on DNA. This AR complex may induce or repress gene transcription. Mutations in the AR gene are associated with androgen insensitivity syndrome, a disorder that causes XY genotypic males to develop as phenotypic females because of their inability to respond to androgens. AR mutations have also been identified in human prostate cancer specimens and the LNCaP human prostate cancer cell line. Monoclonal and polyclonal antibodies to the AR have identified AR-positive cells in a variety of tissues including male and female sexual organs, kidney, liver, adrenal cortex, pituitary gland, skeletal, cardiac, and smooth muscle cells. The androgen receptor has been identified as a 100 kDa protein in SDS/PAGE. G122-434 recognizes an epitope localized within the N-terminal domain (between amino acids 33 and 485) of the human androgen receptor protein. The antibody does not recognize estrogen or progesterone receptors. Purified recombinant human androgen receptor protein was used as immunogen.
- 分子量
- 100 kDa
- 途径
- Nuclear Receptor Transcription Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, Chromatin Binding
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