(4 references)-
- 抗原 See all MEF2D 抗体
- MEF2D (Myocyte Enhancer Factor 2D (MEF2D))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MEF2D antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human MEF2D (Myocyte-specific enhancer factor 2D)
- Top Product
- Discover our top product MEF2D Primary Antibody
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anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 299-509) antibody
MEF2D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 1-521) antibodyMEF2D 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 256-351) antibodyMEF2D 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 3A11 unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 1-110) antibodyMEF2D 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 1-521) antibodyMEF2D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 256-351) antibodyMEF2D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B8 unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (AA 256-351) antibodyMEF2D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D6 unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (pSer180) antibodyMEF2D 适用: 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (pSer444) antibodyMEF2D 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Myocyte Enhancer Factor 2D (MEF2D) (C-Term) antibodyMEF2D 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, Pig, 马, Hamster, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3974-9, (2002) (PubMed).
: "Big mitogen-activated kinase regulates multiple members of the MEF2 protein family." in: The Journal of biological chemistry, Vol. 275, Issue 24, pp. 18534-40, (2000) (PubMed).
: "Regulation of the MEF2 family of transcription factors by p38." in: Molecular and cellular biology, Vol. 19, Issue 1, pp. 21-30, (1999) (PubMed).
: "A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage." in: Development (Cambridge, England), Vol. 118, Issue 4, pp. 1095-106, (1994) (PubMed).
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: "Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3974-9, (2002) (PubMed).
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- 抗原
- MEF2D (Myocyte Enhancer Factor 2D (MEF2D))
- 别名
- MEF2D (MEF2D 产品)
- 别名
- sl1 antibody, sl-1 antibody, XMEF2D antibody, MGC145245 antibody, C80750 antibody, myocyte enhancer factor 2D antibody, MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) antibody, mef2d antibody, MEF2D antibody, Mef2d antibody
- 背景
- MEF2D (Myocyte-specific enhancer factor 2D) is a transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. MEF2D mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. MEF2D plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. MEF2D plays a critical role in the regulation of neuronal apoptosis (By similarity). MEF2D forms a complex with class II HDACs in undifferentiating cells. On myogenic differentiation, HDACs are released into the cytoplasm allowing MEF2s to interact with other proteins for activation. Interacts with HDAC4 (in undifferentiating cells), the interaction translocates MEF2D to nuclear dots. Forms a heterodimer with MEF2A. Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phsophorylation on Ser-180 can be enhanced by EGF.
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