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- 抗原 See all MAP2K3 抗体
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
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抗原表位
- AA 320-334, C-Term
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适用
- 人, 大鼠
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克隆类型
- 多克隆
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标记
- This MAP2K3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminal of human MAP2K3 (320-334 aa), identical to the related mouse and rat sequence.
- Top Product
- Discover our top product MAP2K3 Primary Antibody
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- 限制
- 仅限研究用
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- 溶解方式
- 0.2ml of distilled water will yield a concentration of 500µg/ml.
- 缓冲液
- Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4
- 储存液
- Thimerosal (Merthiolate), Sodium azide
- 储存条件
- -20 °C
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Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5." in: Cytogenetics and cell genetics, Vol. 78, Issue 3-4, pp. 301-3, (1998) (PubMed).
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Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5." in: Cytogenetics and cell genetics, Vol. 78, Issue 3-4, pp. 301-3, (1998) (PubMed).
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- 抗原
- MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
- 别名
- MAP2K3 (MAP2K3 产品)
- 别名
- MAPKK3 antibody, MEK3 antibody, MKK3 antibody, PRKMK3 antibody, SAPKK-2 antibody, SAPKK2 antibody, AW212142 antibody, Prkmk3 antibody, mMKK3b antibody, Mkk3 antibody, mitogen-activated protein kinase kinase 3 antibody, mitogen activated protein kinase kinase 3 antibody, MAP kinase activator XMEK3 antibody, MAP2K3 antibody, Map2k3 antibody, map2k3 antibody
- 背景
- Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.
- 途径
- MAPK Pathway, TLR signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagy, Signaling Events mediated by VEGFR1 and VEGFR2
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