Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Worm: Strongylocentrotus purpuratus LRP6 (Low density lipoprotein receptorrelated protein 6)
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背景
LRP6 (Low density lipoprotein receptor-related protein 6) contains multiple Ldl_recept_b domains (Low-density lipoprotein receptor repeat class B) and a couple of LDLa domains(Low Density Lipoprotein Receptor Class A domain). LDLa domains is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism, the receptor protein binds LDL and transports it into cells by endocytosis.