HSV ICP4 抗体 (N-Term)
HSV ICP4
适用: Herpes Simplex Virus (HSV)
IHC
宿主: 兔
Polyclonal
unconjugated
(1 reference)-
- 抗原 See all HSV ICP4 products
- HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))
- 抗原表位
- N-Term
- 适用
- Herpes Simplex Virus (HSV)
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HSV ICP4 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of Human herpesvirus 2 ICP4 (Trans-acting transcriptional protein ICP4)
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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: "The genome sequence of herpes simplex virus type 2." in: Journal of virology, Vol. 72, Issue 3, pp. 2010-21, (1998) (PubMed).
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: "The genome sequence of herpes simplex virus type 2." in: Journal of virology, Vol. 72, Issue 3, pp. 2010-21, (1998) (PubMed).
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- 抗原
- HSV ICP4 (Herpes Simplex Virus ICP4 (HSV ICP4))
- Abstract
- HSV ICP4 产品
- 物质类
- Viral Protein
- 背景
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ICP4 (Trans-acting transcriptional protein ICP4) is a transcriptional transactivator that binds with high affinity to the sequence 5'-ATCGTC-3'. ICP4 may interact with and recruit specific components of the general transcription machinery to viral promoters and stabilize their formation for transcription initiation. ICP4 negatively regulates its own transcription. This immediate early (EI) protein may be necessary in virion for viral pathogenesis. ICP4 is a homodimer and interacts with transcriptional regulator ICP27, this interaction is required for proper incorporation of ICP4 into virions. The long stretch of Ser is a major site of phosphorylation. Only the phosphorylated forms are capable of interacting with beta or gamma genes. ICP4 belongs to the herpesviridae ICP4/IE140/IE180 family.
Synonyms: IE175 (Infected cell protein 4, Transcriptional activator IE175, Alpha-4 protein)
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