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- 抗原 See all GREM1 抗体
- GREM1 (Gremlin 1 (GREM1))
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抗原表位
- C-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GREM1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠
- 交叉反应 (详细)
- No cross reactivity with other proteins.
- 产品特性
- Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.
- 免疫原
- A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
- 亚型
- IgG
- Top Product
- Discover our top product GREM1 Primary Antibody
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- 限制
- 仅限研究用
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- 状态
- Lyophilized
- 溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
- 缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
- 储存液
- Sodium azide, Thimerosal (Merthiolate)
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
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Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).
: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." in: BMC cancer, Vol. 6, pp. 74, (2006) (PubMed).
: "Office-based testing for fecal occult blood: do only in case of emergency." in: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, (2005) (PubMed).
: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." in: Endocrinology, Vol. 146, Issue 2, pp. 655-65, (2005) (PubMed).
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Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).
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- 抗原
- GREM1 (Gremlin 1 (GREM1))
- 别名
- Gremlin-1 (GREM1 产品)
- 别名
- grem1 antibody, MGC136702 antibody, zgc:136702 antibody, GREM1 antibody, drm antibody, pig2 antibody, dand2 antibody, ihg-2 antibody, gremlin antibody, Cktsf1b1 antibody, Drm antibody, Grem antibody, ld antibody, gremlin-1 antibody, CKTSF1B1 antibody, DAND2 antibody, DRM antibody, GREMLIN antibody, IHG-2 antibody, cktsf1b1 antibody, gremlin 1a, DAN family BMP antagonist antibody, gremlin 1, DAN family BMP antagonist antibody, gremlin 1 antibody, gremlin 1, DAN family BMP antagonist L homeolog antibody, grem1a antibody, GREM1 antibody, LOC662541 antibody, grem1 antibody, Grem1 antibody, grem1.L antibody
- 背景
- Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.
- 途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
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