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- 抗原 See all DDX58 抗体
- DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
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抗原表位
- N-Term
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This DDX58 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DDX58 (Probable ATP-dependent RNA helicase DDX58)
- Top Product
- Discover our top product DDX58 Primary Antibody
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- 限制
- 仅限研究用
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- 储存条件
- 4 °C
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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." in: Cell, Vol. 122, Issue 5, pp. 669-82, (2005) (PubMed).
: "SIKE is an IKK epsilon/TBK1-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways." in: The EMBO journal, Vol. 24, Issue 23, pp. 4018-28, (2005) (PubMed).
: "Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I." in: Journal of virology, Vol. 79, Issue 5, pp. 2689-99, (2005) (PubMed).
: "Retinoic acid-inducible gene-I is induced by interferon-gamma and regulates the expression of interferon-gamma stimulated gene 15 in MCF-7 cells." in: Biochemistry and cell biology = Biochimie et biologie cellulaire, Vol. 82, Issue 3, pp. 401-5, (2004) (PubMed).
: "Retinoic acid-inducible gene-I is induced in endothelial cells by LPS and regulates expression of COX-2." in: Biochemical and biophysical research communications, Vol. 292, Issue 1, pp. 274-9, (2002) (PubMed).
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Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3." in: Cell, Vol. 122, Issue 5, pp. 669-82, (2005) (PubMed).
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- 抗原
- DDX58 (DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58 (DDX58))
- 别名
- DDX58 (DDX58 产品)
- 别名
- RIG-I antibody, RIGI antibody, RLR-1 antibody, 6430573D20Rik antibody, C330021E21 antibody, RHIV-1 antibody, RIG-1 antibody, DExD/H-box helicase 58 antibody, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58 antibody, DEXD/H-box helicase 58 antibody, DDX58 antibody, Ddx58 antibody
- 背景
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DDX58 (Probable ATP-dependent RNA helicase DDX58) is involved in innate immune defense against viruses. Upon interaction with intracellular dsRNA produced during viral replication, triggers a transduction cascade involving MAVS/IPS1, which results in the activation of NF-kappa-B, IRF3 and IRF7 and the induction of the expression of antiviral cytokines such as IFN-beta and RANTES (CCL5). Essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza viruses, Japanese encephalitis virus and HCV. DDX58 (Probable ATP-dependent RNA helicase DDX58) is maintained as a monomer in an autoinhibited state. Upon viral dsRNA binding and conformation shift, homomultimerizes and interacts with MAVS. Interacts with DHX58/LGP2, IKBKE, TBK1 and TMEM173/STING. DDX58 (Probable ATP-dependent RNA helicase DDX58) is present in vascular smooth cells at protein level. DDX58 belongs to the helicase family and contains 2 CARD domains, 1 helicase ATP-binding domain and 1 helicase C-terminal domain.
Synonyms: DEAD-box protein 58, RIG-1 (Retinoic acid-inducible gene 1 protein) - 途径
- Activation of Innate immune Response, Hepatitis C
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