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- 抗原 See all CLOCK 抗体
- CLOCK (Clock Homolog (Mouse) (CLOCK))
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抗原表位
- N-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CLOCK antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC)
- 纯化方法
- Purified by antigen-specific affinity chromatography.
- 免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human CLOCK(Circadian locomoter output cycles protein kaput)
- Top Product
- Discover our top product CLOCK Primary Antibody
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- 应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- This antibody is stored in PBS, 50% glycerol
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
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Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, (2005) (PubMed).
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Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients." in: Brain research. Molecular brain research, Vol. 140, Issue 1-2, pp. 150-4, (2005) (PubMed).
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- 抗原
- CLOCK (Clock Homolog (Mouse) (CLOCK))
- 别名
- CLOCK (CLOCK 产品)
- 背景
- CLOCK(Circadian locomoter output cycles protein kaput) is a circadian regulator that acts as a transcription factor. CLOCK-BMAL1 heterodimers bind to an E-box element (3'-CACGTG-5'), thereby activating transcription of PER1, and possibly of other circadian clock proteins. Mutant CLOCK and BMAL1 form hetereodimers that bind DNA, but fail to activate transcription. CLOCK belongs to the basic helix-loop-helix (bHLH) family of transcription factors. Polymorphisms within the encoded protein have been associated with circadian rhythm sleep disorders. A similar protein in mice is a circadian regulator that acts as a transcription factor and forms a heterodimer with aryl hydrocarbon receptor nuclear translocator-like to activate transcription of mouse period 1.
- 途径
- Regulation of Lipid Metabolism by PPARalpha, Photoperiodism
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