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ABL2 抗体

ABL2 适用: 人, 小鼠 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1H1 unconjugated
产品编号 ABIN965499
发货至: 中国
  • 抗原 See all ABL2 抗体
    ABL2
    适用
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    人, 小鼠
    宿主
    • 87
    • 7
    小鼠
    克隆类型
    • 80
    • 14
    单克隆
    标记
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    This ABL2 antibody is un-conjugated
    应用范围
    • 59
    • 41
    • 26
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    • 6
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    • 2
    • 1
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    Western Blotting (WB), ELISA, Immunofluorescence (IF)
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of ABL2 expressed in E. Coli.
    克隆位点
    1H1
    亚型
    IgG1
    Top Product
    Discover our top product ABL2 Primary Antibody
  • 应用备注
    Western Bloting: 1/500 - 1/2000.
    Immunofluorescence: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.
    限制
    仅限研究用
  • 状态
    Liquid
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C
  • 抗原
    ABL2
    别名
    ABL2 (ABL2 产品)
    别名
    ABLL antibody, ARG antibody, Abll antibody, Arg antibody, AA536808 antibody, ABL proto-oncogene 2, non-receptor tyrosine kinase antibody, v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) antibody, ABL2 antibody, Abl2 antibody
    背景
    ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
    Synonyms: ARG, ABLL, FLJ22224, FLJ31718, FLJ41441
    分子量
    128kDa
    基因ID
    27
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