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ZNF148 抗体

ZNF148 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN964672
发货至: 中国
  • 抗原 See all ZNF148 抗体
    ZNF148 (Zinc Finger Protein 148 (ZNF148))
    适用
    • 42
    • 21
    • 19
    • 8
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    宿主
    • 42
    • 1
    克隆类型
    • 43
    多克隆
    标记
    • 26
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
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    • 1
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    This ZNF148 antibody is un-conjugated
    应用范围
    • 35
    • 18
    • 11
    • 9
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunoprecipitation (IP)
    特异性
    This product was prepared from monospecific antiserum by delipidation and defibrination. This polyclonal antibody is specific for human ZBP-89.  Reactivity with ZBP-89 from other species has not been determined.
    产品特性
    The GI tract abundantly expresses growth factors many of which bind and activate the EGF receptor present on mucosal cells. One such factor is the zinc finger protein (ZBP-89) that binds to a GC-rich DNA element in the gastrin promoter and confers EGF responsiveness. The full-length protein functions as a repressor of growth factor signals regulating the gastrin promoter. Several other growth related promoters are also regulated by ZBP-89. ZBP-89 is one of a family of related transcriptional regulators. It has been reported in recent studies that ZBP-89 regulates growth in part by stimulating the cyclin-dependent kinase inhibitor, p21waf1, in a butyrate-dependent manner through recruitment of the histone acetyl transferase p300. Moreover, ZBP-89 triggers growth arrest in a p53-dependent manner by preventing nuclear export of p53. ZBP-89 also induces apoptosis, but this process occurs independent of p53.
    过滤
    Sterile filtered
    免疫原
    Purified full length ZBP-89 recombinant protein expressed in E.coli.
    Immunogen Type: RecombinantProtein
    Top Product
    Discover our top product ZNF148 Primary Antibody
  • 应用备注
    This polyclonal antibody reacts human ZBP-89 in a variety of immunological assays including western blot and ELISA.  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation. For immunoblotting a 1:5,000 dilution is recommended. A band at approximately 89 kDa corresponding to human ZBP-89 is detected. Human monocytes or macrophages or nuclear extracts from PMA treated U937 cells can be used as a positive control. For ELISA a 1:10,000 to 1:30,000 dilution is recommended. Researchers should determine optimal titers for other applications.
    说明

    Gene Name: ZBP-89

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    90 mg/mL
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.
    有效期
    12 months
  • Ohneda, Ohmori, Ishijima, Nakano, Yamamoto: "Characterization of a functional ZBP-89 binding site that mediates Gata1 gene expression during hematopoietic development." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30187-99, (2009) (PubMed).

    Guyot, Murai, Fujiwara, Valverde-Garduno, Hammett, Wells, Dear, Orkin, Porcher, Vyas: "Characterization of a megakaryocyte-specific enhancer of the key hemopoietic transcription factor GATA1." in: The Journal of biological chemistry, Vol. 281, Issue 19, pp. 13733-42, (2006) (PubMed).

  • 抗原
    ZNF148 (Zinc Finger Protein 148 (ZNF148))
    别名
    ZBP-89 (ZNF148 产品)
    别名
    BERF-1 antibody, BFCOL1 antibody, HT-BETA antibody, ZBP-89 antibody, ZFP148 antibody, pHZ-52 antibody, 2210405J08Rik antibody, AI480666 antibody, AW045217 antibody, Znf148 antibody, Zbp-89 antibody, fb06h05 antibody, wu:fb06h05 antibody, zfp149 antibody, zgc:165342 antibody, SLC12A8 antibody, zinc finger protein 148 antibody, ZNF148 antibody, Zfp148 antibody, znf148 antibody
    背景
    The GI tract abundantly expresses growth factors many of which bind and activate the EGF receptor present on mucosal cells. One such factor is the zinc finger protein (ZBP-89) that binds to a GC-rich DNA element in the gastrin promoter and confers EGF responsiveness. The full-length protein functions as a repressor of growth factor signals regulating the gastrin promoter. Several other growth related promoters are also regulated by ZBP-89. ZBP-89 is one of a family of related transcriptional regulators. It has been reported in recent studies that ZBP-89 regulates growth in part by stimulating the cyclin-dependent kinase inhibitor, p21waf1, in a butyrate-dependent manner through recruitment of the histone acetyl transferase p300. Moreover, ZBP-89 triggers growth arrest in a p53-dependent manner by preventing nuclear export of p53. ZBP-89 also induces apoptosis, but this process occurs independent of p53.
    Synonyms: Transcription factor ZBP89 antibody, Zinc finger DNA binding protein 89 antibody, Zinc finger protein 148 antibody, ZNF 148 antibody
    基因ID
    256711
    UniProt
    Q9UQR1
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