(2 references)-
- 抗原 See all ESRP1 抗体
- ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
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适用
- 小鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This ESRP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 特异性
- This product is an IgG fraction antibody purified from tissue culture supernatant by Protein-A chromatography followed by extensive dialysis against the buffer stated above. This antibody reacts with mouse Esrp-1 protein. A BLAST analysis of the immunizing protein sequence shows 100% homology with Esrp-1 from mouse and a 91% sequence homology with Esrp-1 from human, pig, rat, opossum, horse, cattle, panda, dog, and chimpanzee . The binding epitope of this monoclonal antibody has not been mapped.
- 产品特性
- Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
- 纯化方法
- purified
- 过滤
- Sterile filtered
- 免疫原
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Anti-Esrp-1 was produced by repeated immunizations of full length recombinant mouse Esrp-1 fusion protein.
Immunogen Type: RecombinantProtein - 克隆位点
- 27H12-F3-H5
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product ESRP1 Primary Antibody
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anti-Epithelial Splicing Regulatory Protein 1 (ESRP1) (AA 182-211) antibody
ESRP1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB27304 unconjugated
anti-Epithelial Splicing Regulatory Protein 1 (ESRP1) (AA 1-681) antibodyESRP1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Epithelial Splicing Regulatory Protein 1 (ESRP1) (AA 161-210) antibodyESRP1 适用: 人, 小鼠, 大鼠, 犬, 豚鼠, 兔, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Splicing Regulatory Protein 1 (ESRP1) (AA 1-220) antibodyESRP1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Epithelial Splicing Regulatory Protein 1 (ESRP1) (N-Term) antibodyESRP1 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF, EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- This protein-A purified antibody has been tested for use western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 75.5 kDa in size corresponding to Esrp-1 by western blotting in the appropriate cell lysate or extract.
- 说明
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Gene Name: Esrp1
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store vial at 4 °C prior to restoration. For extended storage aliquot contents and freeze at -20 °C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4 °C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is three (3) months from date of opening.
- 有效期
- 3 months
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: "Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors." in: Molecules and cells, Vol. 37, Issue 1, pp. 81-7, (2014) (PubMed).
: "An ESRP-regulated splicing programme is abrogated during the epithelial-mesenchymal transition." in: The EMBO journal, Vol. 29, Issue 19, pp. 3286-300, (2010) (PubMed).
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: "Pressure-overload cardiac hypertrophy is associated with distinct alternative splicing due to altered expression of splicing factors." in: Molecules and cells, Vol. 37, Issue 1, pp. 81-7, (2014) (PubMed).
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- 抗原
- ESRP1 (Epithelial Splicing Regulatory Protein 1 (ESRP1))
- 别名
- Esrp-1 (ESRP1 产品)
- 别名
- rbm35a antibody, RBM35A antibody, RMB35A antibody, 2210008M09Rik antibody, A630065D16 antibody, BC031468 antibody, Rbm35a antibody, RGD1560481 antibody, wu:fi28a07 antibody, zgc:154050 antibody, epithelial splicing regulatory protein 1 antibody, epithelial splicing regulatory protein 1 L homeolog antibody, ESRP1 antibody, esrp1.L antibody, Esrp1 antibody, esrp1 antibody
- 背景
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Epithelial splicing regulatory protein 1 (Esrp-1) is an mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. It specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2, and also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Esrp-1 acts by directly binding specific sequences in mRNAs. It binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.
Synonyms: Rbm35a, Epithelial splicing regulatory protein 1, RNA-binding protein 35A, RNA-binding motif protein 35A. - 基因ID
- 207920
- NCBI登录号
- NP_918944
- UniProt
- Q3US41
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