(4 references)-
- 抗原 See all MANF 抗体
- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This MANF antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 特异性
- Human MANF
- 交叉反应 （详细）
- No cross-reactivity in MANF-knock out mouse and with CDNF in IHC, slightly cross-reacts with purified CDNF in WB
- 纯化方法
- MANF-affinity purified
- 免疫原
- Recombinant human MANF protein produced using CHO-basedIcosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purifiedfrom cell culture supernatant
- 亚型
- IgG
- Top Product
- Discover our top product MANF Primary Antibody
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anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) antibody
MANF 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 28-182) antibodyMANF 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) antibodyKO Validated MANF 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 116-185) antibodyMANF 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) antibodyMANF 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibodyMANF 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 1-182) antibodyMANF 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (Internal Region) antibodyVerified MANF 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 103-152) antibodyMANF 适用: 人, 小鼠, 大鼠, 兔, Cow, 马, 斑马鱼, 豚鼠, 猴, Pig, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibodyMANF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G12 unconjugated
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- 应用备注
- ELISA1:200 000, Western immunoblotting 1:2000 – 1:6000, IHC, IF. Polyclonal antibody working titer has to be established practically for each particularantigen and assay format
- 说明
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Synonym: ARMET, ARP
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.45 mg/ml
- 缓冲液
- Concentrated ammonium sulphide in PBS pH 7.4.
- 注意事项
- As product is (NH4)2SO4precipitate, mix well by pipetting or vortexing prior use.
- 储存条件
- 4 °C
- 储存方法
- This product is shipped in non-frozen liquid form in ambient conditions
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: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).
: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." in: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." in: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." in: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
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: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).
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- 抗原
- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
- 别名
- MANF (MANF 产品)
- 背景
- MANF is a trophic factor for midbrain dopamine neuronsin vivo. It prevents the 6-OHDA-induced degeneration of dopamine neurons in rodent models of Parkinson’sdisease (Lindholm et al., 2008, Voutilainen et al., 2009). When administeredafter 6-OHDA-lesioning it restores the dopaminergic function and prevents degenerationof dopamine neurons in substantia nigra pars compacta
- UniProt
- P55145
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