STARD5 antibody, MGC131265 antibody, DKFZp469N2125 antibody, 2310058G22Rik antibody, AI607880 antibody, D7Ertd152e antibody, RGD1561783 antibody, StAR related lipid transfer domain containing 5 antibody, StAR related lipid transfer domain containing 5 S homeolog antibody, StAR-related lipid transfer (START) domain containing 5 antibody, StAR-related lipid transfer domain containing 5 antibody, STARD5 antibody, stard5.S antibody, Stard5 antibody
背景
Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1, MIM 184756) and by liver X receptors (e.g., LXRA, MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR, MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002 [PubMed 12011452]).Synonyms: START domain-containing protein 5, StAR-related lipid transfer protein 5